TREX1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TREX1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TREX1 at tissue level.

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0032680Biological processregulation of tumor necrosis factor production
GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0006281Biological processDNA repair
GO_0034614Biological processcellular response to reactive oxygen species
GO_0043457Biological processregulation of cellular respiration
GO_0008340Biological processdetermination of adult lifespan
GO_0045184Biological processestablishment of protein localization
GO_0006308Biological processDNA catabolic process
GO_0051607Biological processdefense response to virus
GO_0061635Biological processregulation of protein complex stability
GO_0072711Biological processcellular response to hydroxyurea
GO_0160049Biological processnegative regulation of cGAS/STING signaling pathway
GO_0001822Biological processkidney development
GO_0019217Biological processregulation of fatty acid metabolic process
GO_0046890Biological processregulation of lipid biosynthetic process
GO_0002637Biological processregulation of immunoglobulin production
GO_0050727Biological processregulation of inflammatory response
GO_0006110Biological processregulation of glycolytic process
GO_0006260Biological processDNA replication
GO_0002437Biological processinflammatory response to antigenic stimulus
GO_0032479Biological processregulation of type I interferon production
GO_0071480Biological processcellular response to gamma radiation
GO_1904161Biological processDNA synthesis involved in UV-damage excision repair
GO_0035458Biological processcellular response to interferon-beta
GO_0002383Biological processimmune response in brain or nervous system
GO_0097281Biological processimmune complex formation
GO_0045824Biological processnegative regulation of innate immune response
GO_0002253Biological processactivation of immune response
GO_0043277Biological processapoptotic cell clearance
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0003228Biological processatrial cardiac muscle tissue development
GO_0006259Biological processDNA metabolic process
GO_0050821Biological processprotein stabilization
GO_0003015Biological processheart process
GO_0006304Biological processDNA modification
GO_0001568Biological processblood vessel development
GO_0002457Biological processT cell antigen processing and presentation
GO_0050863Biological processregulation of T cell activation
GO_0002281Biological processmacrophage activation involved in immune response
GO_1905671Biological processregulation of lysosome organization
GO_0035781Biological processCD86 biosynthetic process
GO_0032197Biological processretrotransposition
GO_0006310Biological processDNA recombination
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0031571Biological processmitotic G1 DNA damage checkpoint signaling
GO_0006298Biological processmismatch repair
GO_0002320Biological processlymphoid progenitor cell differentiation
GO_0003007Biological processheart morphogenesis
GO_0043596Cellular componentnuclear replication fork
GO_0032993Cellular componentprotein-DNA complex
GO_0008250Cellular componentoligosaccharyltransferase complex
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005635Cellular componentnuclear envelope
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042803Molecular functionprotein homodimerization activity
GO_0008301Molecular functionDNA binding, bending
GO_0032407Molecular functionMutSalpha complex binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0008296Molecular function3'-5'-DNA exonuclease activity
GO_0032405Molecular functionMutLalpha complex binding
GO_0000287Molecular functionmagnesium ion binding
GO_0008408Molecular function3'-5' exonuclease activity
GO_0050699Molecular functionWW domain binding
GO_0008311Molecular functiondouble-stranded DNA 3'-5' DNA exonuclease activity
GO_0046872Molecular functionmetal ion binding
GO_0032558Molecular functionadenyl deoxyribonucleotide binding

IV. Literature review

[source]
Gene nameTREX1
Protein nameThree-prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (Deoxyribonuclease III) (DNase III)
exodeoxyribonuclease III (EC 3.1.11.2)
Alternative protein TREX1
SynonymshCG_1997849
DescriptionFUNCTION: Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini . Prevents cell-intrinsic initiation of autoimmunity . Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements . Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation . Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation . Unless degraded, these DNA fragments accumulate in the cytosol and activate the cGAS-STING innate immune signaling, leading to the production of type I interferon . Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates . Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light . During GZMA-mediated cell death, contributes to DNA damage in concert with NME1 . NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair . .

AccessionsENST00000444177.1 [Q9NSU2-2]
ENST00000492235.2
ENST00000635452.2
Q6IAN5
ENST00000625293.3 [Q9NSU2-3]
Q9NSU2
ENST00000456089.1
L8E8B0
ENST00000433541.1
Q5TZT0
C9J052