Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| classical monocyte | 8 studies | 23% ± 7% | |
| myeloid cell | 4 studies | 17% ± 1% | |
| epithelial cell | 4 studies | 20% ± 3% | |
| endothelial cell | 3 studies | 21% ± 2% | |
| glutamatergic neuron | 3 studies | 25% ± 8% | |
| dendritic cell | 3 studies | 36% ± 11% | |
| macrophage | 3 studies | 17% ± 0% |
Insufficient scRNA-seq data for expression of TYK2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 4289.43 | 1445 / 1445 | 100% | 43.63 | 183 / 183 |
| pancreas | 100% | 3955.64 | 328 / 328 | 100% | 42.07 | 178 / 178 |
| prostate | 100% | 6690.48 | 245 / 245 | 100% | 37.21 | 502 / 502 |
| skin | 100% | 5669.05 | 1809 / 1809 | 100% | 47.18 | 472 / 472 |
| stomach | 100% | 4561.46 | 359 / 359 | 100% | 37.13 | 286 / 286 |
| uterus | 100% | 6062.45 | 170 / 170 | 100% | 50.25 | 459 / 459 |
| breast | 100% | 6370.21 | 459 / 459 | 100% | 37.52 | 1117 / 1118 |
| thymus | 100% | 7311.72 | 653 / 653 | 100% | 45.46 | 604 / 605 |
| lung | 100% | 8151.81 | 578 / 578 | 100% | 40.42 | 1153 / 1155 |
| intestine | 100% | 5997.07 | 966 / 966 | 100% | 37.05 | 526 / 527 |
| liver | 100% | 4826.62 | 226 / 226 | 100% | 30.46 | 405 / 406 |
| adrenal gland | 100% | 5648.95 | 258 / 258 | 100% | 34.49 | 229 / 230 |
| kidney | 100% | 5809.29 | 89 / 89 | 100% | 37.99 | 897 / 901 |
| bladder | 100% | 5210.90 | 21 / 21 | 99% | 41.82 | 501 / 504 |
| ovary | 100% | 6099.13 | 180 / 180 | 99% | 40.72 | 426 / 430 |
| brain | 99% | 3527.64 | 2607 / 2642 | 100% | 48.05 | 705 / 705 |
| adipose | 100% | 5954.92 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 34.34 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 86.69 | 29 / 29 |
| spleen | 100% | 13875.90 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 60.84 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 21.20 | 1 / 1 |
| peripheral blood | 100% | 13775.26 | 928 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3998.38 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 3379.83 | 856 / 861 | 0% | 0 | 0 / 0 |
| muscle | 99% | 2946.38 | 796 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0042102 | Biological process | positive regulation of T cell proliferation |
| GO_2000318 | Biological process | positive regulation of T-helper 17 type immune response |
| GO_0032819 | Biological process | positive regulation of natural killer cell proliferation |
| GO_0060397 | Biological process | growth hormone receptor signaling pathway via JAK-STAT |
| GO_0060333 | Biological process | type II interferon-mediated signaling pathway |
| GO_0140105 | Biological process | interleukin-10-mediated signaling pathway |
| GO_0006955 | Biological process | immune response |
| GO_0098586 | Biological process | cellular response to virus |
| GO_0060337 | Biological process | type I interferon-mediated signaling pathway |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0051142 | Biological process | positive regulation of NK T cell proliferation |
| GO_0030154 | Biological process | cell differentiation |
| GO_0035722 | Biological process | interleukin-12-mediated signaling pathway |
| GO_0032729 | Biological process | positive regulation of type II interferon production |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0046427 | Biological process | positive regulation of receptor signaling pathway via JAK-STAT |
| GO_0007259 | Biological process | cell surface receptor signaling pathway via JAK-STAT |
| GO_0038196 | Biological process | type III interferon-mediated signaling pathway |
| GO_0032740 | Biological process | positive regulation of interleukin-17 production |
| GO_1900182 | Biological process | positive regulation of protein localization to nucleus |
| GO_0072536 | Cellular component | interleukin-23 receptor complex |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031234 | Cellular component | extrinsic component of cytoplasmic side of plasma membrane |
| GO_0009898 | Cellular component | cytoplasmic side of plasma membrane |
| GO_0019897 | Cellular component | extrinsic component of plasma membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0042022 | Cellular component | interleukin-12 receptor complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0004715 | Molecular function | non-membrane spanning protein tyrosine kinase activity |
| GO_0031702 | Molecular function | type 1 angiotensin receptor binding |
| GO_0004713 | Molecular function | protein tyrosine kinase activity |
| GO_0005131 | Molecular function | growth hormone receptor binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TYK2 |
| Protein name | Non-receptor tyrosine-protein kinase TYK2 Tyrosine kinase 2 Tyrosine-protein kinase (EC 2.7.10.2) Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) |
| Synonyms | |
| Description | FUNCTION: Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity . Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling . Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 . The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 . In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members . In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes . Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling . . |
| Accessions | E9PM19 H0YE41 ENST00000699360.1 K7EJR6 ENST00000527481.3 ENST00000699358.1 A0A8E7DA23 A0A8V8TN89 ENST00000530560.5 ENST00000524470.2 A0A8V8TNM9 ENST00000699362.1 A0A8V8TN50 ENST00000531836.5 ENST00000525220.1 ENST00000525621.6 P29597 A0A8V8TN95 ENST00000524462.5 ENST00000533334.2 E9PQL2 A0A8V8TPH2 ENST00000531836.6 ENST00000699355.1 ENST00000699363.1 E9PQE9 A0A8V8TPX5 ENST00000699371.1 ENST00000699359.1 H0YCT7 K7EM33 A0A8V8TN55 ENST00000525976.6 ENST00000699365.1 ENST00000530829.2 A0A8V8TPJ3 A0A8V8TPJ0 H0YE24 ENST00000699368.1 |
