IRF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035666Biological processTRIF-dependent toll-like receptor signaling pathway
GO_0031663Biological processlipopolysaccharide-mediated signaling pathway
GO_0002376Biological processimmune system process
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0060340Biological processpositive regulation of type I interferon-mediated signaling pathway
GO_0045087Biological processinnate immune response
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0051607Biological processdefense response to virus
GO_0006974Biological processDNA damage response
GO_0032481Biological processpositive regulation of type I interferon production
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050727Biological processregulation of inflammatory response
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0023019Biological processsignal transduction involved in regulation of gene expression
GO_0098586Biological processcellular response to virus
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0071888Biological processmacrophage apoptotic process
GO_0140896Biological processcGAS/STING signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0097300Biological processprogrammed necrotic cell death
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0006915Biological processapoptotic process
GO_0071360Biological processcellular response to exogenous dsRNA
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0039530Biological processMDA-5 signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0019904Molecular functionprotein domain specific binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001216Molecular functionDNA-binding transcription activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIRF3
Protein nameInterferon regulatory factor 3b
Interferon regulatory factor 3d
Interferon regulatory factor 3 (IRF-3)
Interferon regulatory factor 3c (Interferon regulatory factor 3f)
Interferon regulatory factor 3
Interferon regulatory factor 3e
IRF3 protein (Interferon regulatory factor 3, isoform CRA_b)
Interferon regulatory factor 3a
SynonymshCG_21108
DescriptionFUNCTION: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses . Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters . Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction . Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases . This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes . Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages . In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis . Key transcription factor regulating the IFN response during SARS-CoV-2 infection . .

AccessionsENST00000595034.5
ENST00000599144.5
M0QZB8
ENST00000593922.5
Q96GL3
ENST00000600022.5 [Q14653-3]
ENST00000597636.5
ENST00000593818.5
ENST00000601809.5
M0QZB7
E2GIM9
M0QYT9
ENST00000600911.5
ENST00000377139.8 [Q14653-1]
ENST00000593337.5
ENST00000598808.5
M0R3E9
E2GIM8
ENST00000601291.5 [Q14653-4]
ENST00000596788.1
M0R3C2
M0QX56
M0R0R8
M0R3H7
M0QXC8
ENST00000596822.5
E2GIM7
M0R007
ENST00000377135.8
ENST00000599223.5 [Q14653-2]
ENST00000442265.2 [Q14653-5]
ENST00000597198.5 [Q14653-1]
ENST00000598108.5
ENST00000601373.5
ENST00000596756.5
Q14653
ENST00000596765.5 [Q14653-3]
M0R0X9
ENST00000600453.1
ENST00000309877.11 [Q14653-1]
M0QYX3
E2GIM5
Q71U93
M0R205
E2GIM6