Biological process

TRIF-dependent TLR signaling pathway, TRIF-dependent toll-like receptor signalling pathway, Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR signaling pathway

The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.