CD274 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CD274 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CD274 at tissue level.

III. Associated gene sets

GO_0035666Biological processTRIF-dependent toll-like receptor signaling pathway
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0002841Biological processnegative regulation of T cell mediated immune response to tumor cell
GO_0034097Biological processresponse to cytokine
GO_0007165Biological processsignal transduction
GO_0031295Biological processT cell costimulation
GO_0070232Biological processregulation of T cell apoptotic process
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_0032693Biological processnegative regulation of interleukin-10 production
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_1903556Biological processnegative regulation of tumor necrosis factor superfamily cytokine production
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030335Biological processpositive regulation of cell migration
GO_0046007Biological processnegative regulation of activated T cell proliferation
GO_0042130Biological processnegative regulation of T cell proliferation
GO_1905404Biological processpositive regulation of activated CD8-positive, alpha-beta T cell apoptotic process
GO_0071222Biological processcellular response to lipopolysaccharide
GO_1905399Biological processregulation of activated CD4-positive, alpha-beta T cell apoptotic process
GO_0032689Biological processnegative regulation of type II interferon production
GO_2000562Biological processnegative regulation of CD4-positive, alpha-beta T cell proliferation
GO_0046006Biological processregulation of activated T cell proliferation
GO_2001186Biological processnegative regulation of CD8-positive, alpha-beta T cell activation
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0031901Cellular componentearly endosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0005654Cellular componentnucleoplasm
GO_0015629Cellular componentactin cytoskeleton
GO_0005634Cellular componentnucleus
GO_0048018Molecular functionreceptor ligand activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD274
Protein nameProgrammed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
SynonymsB7H1
PDL1
PDCD1L1
PDCD1LG1
DescriptionFUNCTION: Plays a critical role in induction and maintenance of immune tolerance to self . As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response . Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) . Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis . .; FUNCTION: The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival . The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (By similarity). .

AccessionsENST00000381573.8 [Q9NZQ7-2]
Q9NZQ7
ENST00000381577.4 [Q9NZQ7-1]