TLR4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TLR4 at tissue level.

III. Associated gene sets

GO_0007254Biological processJNK cascade
GO_0032722Biological processpositive regulation of chemokine production
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0070427Biological processnucleotide-binding oligomerization domain containing 1 signaling pathway
GO_0006954Biological processinflammatory response
GO_0071260Biological processcellular response to mechanical stimulus
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0032732Biological processpositive regulation of interleukin-1 production
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0006955Biological processimmune response
GO_0042088Biological processT-helper 1 type immune response
GO_0070434Biological processpositive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0006909Biological processphagocytosis
GO_0002730Biological processregulation of dendritic cell cytokine production
GO_1904466Biological processpositive regulation of matrix metallopeptidase secretion
GO_0032689Biological processnegative regulation of type II interferon production
GO_0014002Biological processastrocyte development
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0035666Biological processTRIF-dependent toll-like receptor signaling pathway
GO_0045348Biological processpositive regulation of MHC class II biosynthetic process
GO_0002537Biological processnitric oxide production involved in inflammatory response
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0045087Biological processinnate immune response
GO_0010628Biological processpositive regulation of gene expression
GO_1903428Biological processpositive regulation of reactive oxygen species biosynthetic process
GO_0002322Biological processB cell proliferation involved in immune response
GO_0014911Biological processpositive regulation of smooth muscle cell migration
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0043032Biological processpositive regulation of macrophage activation
GO_2000343Biological processpositive regulation of chemokine (C-X-C motif) ligand 2 production
GO_0051403Biological processstress-activated MAPK cascade
GO_1903974Biological processpositive regulation of cellular response to macrophage colony-stimulating factor stimulus
GO_0007252Biological processI-kappaB phosphorylation
GO_0070371Biological processERK1 and ERK2 cascade
GO_0071223Biological processcellular response to lipoteichoic acid
GO_0006809Biological processnitric oxide biosynthetic process
GO_0045429Biological processpositive regulation of nitric oxide biosynthetic process
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0070430Biological processpositive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0070431Biological processnucleotide-binding oligomerization domain containing 2 signaling pathway
GO_0010467Biological processgene expression
GO_0050729Biological processpositive regulation of inflammatory response
GO_0032700Biological processnegative regulation of interleukin-17 production
GO_0060729Biological processintestinal epithelial structure maintenance
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0036120Biological processcellular response to platelet-derived growth factor stimulus
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0002755Biological processMyD88-dependent toll-like receptor signaling pathway
GO_0042116Biological processmacrophage activation
GO_2001238Biological processpositive regulation of extrinsic apoptotic signaling pathway
GO_0032874Biological processpositive regulation of stress-activated MAPK cascade
GO_0051770Biological processpositive regulation of nitric-oxide synthase biosynthetic process
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0060907Biological processpositive regulation of macrophage cytokine production
GO_0010572Biological processpositive regulation of platelet activation
GO_1904646Biological processcellular response to amyloid-beta
GO_0140052Biological processcellular response to oxidised low-density lipoprotein particle stimulus
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071346Biological processcellular response to type II interferon
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0031663Biological processlipopolysaccharide-mediated signaling pathway
GO_0002224Biological processtoll-like receptor signaling pathway
GO_0046330Biological processpositive regulation of JNK cascade
GO_0032707Biological processnegative regulation of interleukin-23 production
GO_0032735Biological processpositive regulation of interleukin-12 production
GO_0045342Biological processMHC class II biosynthetic process
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_0016046Biological processdetection of fungus
GO_0014004Biological processmicroglia differentiation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0042742Biological processdefense response to bacterium
GO_0002246Biological processwound healing involved in inflammatory response
GO_0032729Biological processpositive regulation of type II interferon production
GO_0032497Biological processdetection of lipopolysaccharide
GO_0032496Biological processresponse to lipopolysaccharide
GO_0045671Biological processnegative regulation of osteoclast differentiation
GO_0009986Cellular componentcell surface
GO_0010008Cellular componentendosome membrane
GO_0001726Cellular componentruffle
GO_0046696Cellular componentlipopolysaccharide receptor complex
GO_0009897Cellular componentexternal side of plasma membrane
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0005769Cellular componentearly endosome
GO_0001891Cellular componentphagocytic cup
GO_0005737Cellular componentcytoplasm
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0001875Molecular functionlipopolysaccharide immune receptor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0038023Molecular functionsignaling receptor activity
GO_0001540Molecular functionamyloid-beta binding
GO_0005102Molecular functionsignaling receptor binding
GO_0061809Molecular functionNAD+ nucleotidase, cyclic ADP-ribose generating
GO_0001530Molecular functionlipopolysaccharide binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTLR4
Protein nameToll like receptor 4 protein
Toll-like receptor 4 (hToll) (CD antigen CD284)
Toll like receptor 4
Toll-like receptor 4
SynonymsTLR-4
DescriptionFUNCTION: Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways . At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) . Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+) . Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production . In addition to the secretion of proinflammatory cytokines, initiates the activation of NLRP3 inflammasome and formation of a positive feedback loop between autophagy and NF-kappa-B signaling cascade . In complex with TLR6, promotes inflammation in monocytes/macrophages by associating with TLR6 and the receptor CD86 . Upon ligand binding, such as oxLDL or amyloid-beta 42, the TLR4:TLR6 complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway . In myeloid dendritic cells, vesicular stomatitis virus glycoprotein G but not LPS promotes the activation of IRF7, leading to type I IFN production in a CD14-dependent manner . Required for the migration-promoting effects of ZG16B/PAUF on pancreatic cancer cells. .

AccessionsD2JYI4
D2JYI3
A0A2R8Y7P4
D2JYI6
ENST00000472304.2
D1CS55
A0A3Q8PZA0
D2JYI9
O00206
D2JYI2
D2JYI7
D2JYI5
A0A7D5XLN4
ENST00000355622.8 [O00206-1]
ENST00000394487.5 [O00206-2]
D2JYI8