MAP3K7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035666Biological processTRIF-dependent toll-like receptor signaling pathway
GO_0002755Biological processMyD88-dependent toll-like receptor signaling pathway
GO_0043507Biological processpositive regulation of JUN kinase activity
GO_0007254Biological processJNK cascade
GO_0002726Biological processpositive regulation of T cell cytokine production
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0006954Biological processinflammatory response
GO_0038173Biological processinterleukin-17A-mediated signaling pathway
GO_0000165Biological processMAPK cascade
GO_0010629Biological processnegative regulation of gene expression
GO_1904754Biological processpositive regulation of vascular associated smooth muscle cell migration
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0034138Biological processtoll-like receptor 3 signaling pathway
GO_0071456Biological processcellular response to hypoxia
GO_0043276Biological processanoikis
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0038172Biological processinterleukin-33-mediated signaling pathway
GO_0038095Biological processFc-epsilon receptor signaling pathway
GO_0045787Biological processpositive regulation of cell cycle
GO_0050852Biological processT cell receptor signaling pathway
GO_0006338Biological processchromatin remodeling
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0002223Biological processstimulatory C-type lectin receptor signaling pathway
GO_0051403Biological processstress-activated MAPK cascade
GO_0006955Biological processimmune response
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0007252Biological processI-kappaB phosphorylation
GO_0016239Biological processpositive regulation of macroautophagy
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0042742Biological processdefense response to bacterium
GO_0045793Biological processpositive regulation of cell size
GO_0038066Biological processp38MAPK cascade
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_1904707Biological processpositive regulation of vascular associated smooth muscle cell proliferation
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0035872Biological processnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO_1904385Biological processcellular response to angiotensin
GO_0005886Cellular componentplasma membrane
GO_0005829Cellular componentcytosol
GO_0140672Cellular componentATAC complex
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005634Cellular componentnucleus
GO_0004707Molecular functionMAP kinase activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0008349Molecular functionMAP kinase kinase kinase kinase activity
GO_1990450Molecular functionlinear polyubiquitin binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0000287Molecular functionmagnesium ion binding
GO_0004709Molecular functionMAP kinase kinase kinase activity
GO_0001223Molecular functiontranscription coactivator binding
GO_0120283Molecular functionprotein serine/threonine kinase binding
GO_0097110Molecular functionscaffold protein binding
GO_0005114Molecular functiontype II transforming growth factor beta receptor binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0035173Molecular functionhistone kinase activity

IV. Literature review

[source]
Gene nameMAP3K7
Protein namemitogen-activated protein kinase kinase kinase (EC 2.7.11.25)
Mitogen-activated protein kinase kinase kinase 7
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
SynonymsTAK1
DescriptionFUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway . Plays an important role in the cascades of cellular responses evoked by changes in the environment . Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR) . Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7 . These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1) . Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex . Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation . In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B . Promotes TRIM5 capsid-specific restriction activity . Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles . .

AccessionsENST00000703101.1
ENST00000700583.1
A0A8V8TPV8
A0A8V8TQ28
A0A8V8TQE8
A0A8V8TRC0
O43318
A0A8V8TR14
ENST00000700585.1
A0A8V8TR17
ENST00000369332.7 [O43318-2]
A0A8V8TRC6
A0A8V8TPW3
ENST00000700580.1 [O43318-2]
ENST00000703100.1
A0A8V8TQF2
ENST00000700582.1
ENST00000700584.1
ENST00000700589.1
ENST00000700581.1
A0A8V8TQF4
ENST00000700591.1
ENST00000700592.1
A0A8V8TRC2
ENST00000369329.8 [O43318-1]
A0A8V8TQL7
ENST00000369327.7 [O43318-4]
ENST00000700587.1
ENST00000369325.7 [O43318-3]
A0A8V8TQF8
ENST00000700593.1
ENST00000700594.1