TICAM2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TICAM2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TICAM2 at tissue level.

III. Associated gene sets

GO_0035666Biological processTRIF-dependent toll-like receptor signaling pathway
GO_0006954Biological processinflammatory response
GO_0045087Biological processinnate immune response
GO_0032481Biological processpositive regulation of type I interferon production
GO_0034145Biological processpositive regulation of toll-like receptor 4 signaling pathway
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0006909Biological processphagocytosis
GO_0071222Biological processcellular response to lipopolysaccharide
GO_2000494Biological processpositive regulation of interleukin-18-mediated signaling pathway
GO_0035669Biological processTRAM-dependent toll-like receptor 4 signaling pathway
GO_0030667Cellular componentsecretory granule membrane
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0031901Cellular componentearly endosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005783Cellular componentendoplasmic reticulum
GO_0001891Cellular componentphagocytic cup
GO_0042995Cellular componentcell projection
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0060090Molecular functionmolecular adaptor activity
GO_0035591Molecular functionsignaling adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTICAM2
Protein nameTIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4)
SynonymsTRAM
TIRP
TIRAP3
DescriptionFUNCTION: Functions as a sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction . In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement . Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response . Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria . .; FUNCTION: [Isoform 2]: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.

AccessionsENST00000427199.3 [Q86XR7-1]
Q86XR7