TRAF6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000679Biological processpositive regulation of transcription regulatory region DNA binding
GO_0038172Biological processinterleukin-33-mediated signaling pathway
GO_0002637Biological processregulation of immunoglobulin production
GO_0045672Biological processpositive regulation of osteoclast differentiation
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0042088Biological processT-helper 1 type immune response
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0043011Biological processmyeloid dendritic cell differentiation
GO_1904996Biological processpositive regulation of leukocyte adhesion to vascular endothelial cell
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0035666Biological processTRIF-dependent toll-like receptor signaling pathway
GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0002726Biological processpositive regulation of T cell cytokine production
GO_0000209Biological processprotein polyubiquitination
GO_0001701Biological processin utero embryonic development
GO_0000045Biological processautophagosome assembly
GO_0045087Biological processinnate immune response
GO_0051865Biological processprotein autoubiquitination
GO_0050852Biological processT cell receptor signaling pathway
GO_0032147Biological processactivation of protein kinase activity
GO_0071345Biological processcellular response to cytokine stimulus
GO_0042981Biological processregulation of apoptotic process
GO_0001843Biological processneural tube closure
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0045453Biological processbone resorption
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0002755Biological processMyD88-dependent toll-like receptor signaling pathway
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0030316Biological processosteoclast differentiation
GO_0031666Biological processpositive regulation of lipopolysaccharide-mediated signaling pathway
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0034138Biological processtoll-like receptor 3 signaling pathway
GO_0032481Biological processpositive regulation of type I interferon production
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0002223Biological processstimulatory C-type lectin receptor signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0097400Biological processinterleukin-17-mediated signaling pathway
GO_0043507Biological processpositive regulation of JUN kinase activity
GO_0031663Biological processlipopolysaccharide-mediated signaling pathway
GO_0038173Biological processinterleukin-17A-mediated signaling pathway
GO_0006974Biological processDNA damage response
GO_0032735Biological processpositive regulation of interleukin-12 production
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0038095Biological processFc-epsilon receptor signaling pathway
GO_0070555Biological processresponse to interleukin-1
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0019886Biological processantigen processing and presentation of exogenous peptide antigen via MHC class II
GO_0001503Biological processossification
GO_0140374Biological processantiviral innate immune response
GO_0031234Cellular componentextrinsic component of cytoplasmic side of plasma membrane
GO_0010008Cellular componentendosome membrane
GO_0005634Cellular componentnucleus
GO_0098802Cellular componentplasma membrane signaling receptor complex
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0032991Cellular componentprotein-containing complex
GO_0035631Cellular componentCD40 receptor complex
GO_0005737Cellular componentcytoplasm
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0034450Molecular functionubiquitin-ubiquitin ligase activity
GO_0042802Molecular functionidentical protein binding
GO_0008270Molecular functionzinc ion binding
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0042826Molecular functionhistone deacetylase binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0031624Molecular functionubiquitin conjugating enzyme binding
GO_0043422Molecular functionprotein kinase B binding
GO_0004842Molecular functionubiquitin-protein transferase activity

IV. Literature review

[source]
Gene nameTRAF6
Protein nameTNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
SynonymsRNF85
DescriptionFUNCTION: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 . Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation . Leads to the activation of NF-kappa-B and JUN . Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity). Represses c-Myb-mediated transactivation, in B-lymphocytes . Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor . Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (By similarity). Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity). Participates also in the TCR signaling by ubiquitinating LAT . .

AccessionsQ9Y4K3
ENST00000348124.5
ENST00000526995.6