TICAM1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TICAM1 at tissue level.

III. Associated gene sets

GO_0035666Biological processTRIF-dependent toll-like receptor signaling pathway
GO_0031663Biological processlipopolysaccharide-mediated signaling pathway
GO_0002224Biological processtoll-like receptor signaling pathway
GO_0032722Biological processpositive regulation of chemokine production
GO_0097190Biological processapoptotic signaling pathway
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0006954Biological processinflammatory response
GO_0045087Biological processinnate immune response
GO_0002735Biological processpositive regulation of myeloid dendritic cell cytokine production
GO_0034138Biological processtoll-like receptor 3 signaling pathway
GO_0043330Biological processresponse to exogenous dsRNA
GO_0051607Biological processdefense response to virus
GO_0010628Biological processpositive regulation of gene expression
GO_0032481Biological processpositive regulation of type I interferon production
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0010508Biological processpositive regulation of autophagy
GO_0006809Biological processnitric oxide biosynthetic process
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0032816Biological processpositive regulation of natural killer cell activation
GO_0045429Biological processpositive regulation of nitric oxide biosynthetic process
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0060907Biological processpositive regulation of macrophage cytokine production
GO_0043254Biological processregulation of protein-containing complex assembly
GO_0002281Biological processmacrophage activation involved in immune response
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0042100Biological processB cell proliferation
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0140052Biological processcellular response to oxidised low-density lipoprotein particle stimulus
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0097342Cellular componentripoptosome
GO_0005739Cellular componentmitochondrion
GO_0005769Cellular componentearly endosome
GO_0005829Cellular componentcytosol
GO_0005776Cellular componentautophagosome
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0060090Molecular functionmolecular adaptor activity
GO_0019901Molecular functionprotein kinase binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTICAM1
Protein nameTIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)
SynonymsTRIF
PRVTIRB
DescriptionFUNCTION: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis . Ligand binding to these receptors results in TRIF recruitment through its TIR domain . Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively . Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens . Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines (By similarity). .

AccessionsQ8IUC6
ENST00000248244.6