IKBKB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035666Biological processTRIF-dependent toll-like receptor signaling pathway
GO_0002755Biological processMyD88-dependent toll-like receptor signaling pathway
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0006954Biological processinflammatory response
GO_0072659Biological processprotein localization to plasma membrane
GO_0045087Biological processinnate immune response
GO_0035509Biological processnegative regulation of myosin-light-chain-phosphatase activity
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0009615Biological processresponse to virus
GO_0034138Biological processtoll-like receptor 3 signaling pathway
GO_1903347Biological processnegative regulation of bicellular tight junction assembly
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0042325Biological processregulation of phosphorylation
GO_0038095Biological processFc-epsilon receptor signaling pathway
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0050852Biological processT cell receptor signaling pathway
GO_0002223Biological processstimulatory C-type lectin receptor signaling pathway
GO_0051403Biological processstress-activated MAPK cascade
GO_0002479Biological processantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0006468Biological processprotein phosphorylation
GO_1903140Biological processregulation of establishment of endothelial barrier
GO_0030866Biological processcortical actin cytoskeleton organization
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0051604Biological processprotein maturation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0045121Cellular componentmembrane raft
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0035631Cellular componentCD40 receptor complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0008385Cellular componentIkappaB kinase complex
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0008384Molecular functionIkappaB kinase activity
GO_1990459Molecular functiontransferrin receptor binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0097110Molecular functionscaffold protein binding
GO_0005524Molecular functionATP binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIKBKB
Protein nameIKBKB protein
Inhibitor of nuclear factor kappa B kinase subunit beta
IkappaB kinase (EC 2.7.11.10)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, isoform CRA_a (cDNA FLJ33978 fis, clone DFNES2004354, highly similar to Inhibitor of nuclear factor kappa B kinase subunit beta)
SynonymsIKKB
hCG_17395
DescriptionFUNCTION: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses . Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation . Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues . These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome . In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis . In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE . IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs . Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor . Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 . Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus . .

AccessionsENST00000342222.6
O14920
A0A7P0SVL5
A0A7I2V4L0
E5RFG5
ENST00000517890.5
ENST00000518679.5
E5RIW0
ENST00000523105.5
ENST00000676525.1
B3KRB7
ENST00000517812.5
A0A499FJS7
ENST00000520655.5
ENST00000520835.7
A1L159
A0A7P0NCV2
E5RGA0
Q32ND9
ENST00000629753.2
ENST00000523517.5
ENST00000519733.5
E5RFT3
ENST00000517388.5
G3V105
ENST00000521661.5
ENST00000520810.6 [O14920-1]
ENST00000416505.7
ENST00000518983.1
E5RJH2
E5RGW5
ENST00000522147.4
J3KNS5
ENST00000649612.3