TLR6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TLR6 at tissue level.

III. Associated gene sets

GO_0035666Biological processTRIF-dependent toll-like receptor signaling pathway
GO_0002755Biological processMyD88-dependent toll-like receptor signaling pathway
GO_0043507Biological processpositive regulation of JUN kinase activity
GO_0002224Biological processtoll-like receptor signaling pathway
GO_2001238Biological processpositive regulation of extrinsic apoptotic signaling pathway
GO_0006954Biological processinflammatory response
GO_0001774Biological processmicroglial cell activation
GO_0034136Biological processnegative regulation of toll-like receptor 2 signaling pathway
GO_0038124Biological processtoll-like receptor TLR6:TLR2 signaling pathway
GO_0071726Biological processcellular response to diacyl bacterial lipopeptide
GO_0045087Biological processinnate immune response
GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_1903428Biological processpositive regulation of reactive oxygen species biosynthetic process
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0043032Biological processpositive regulation of macrophage activation
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0006955Biological processimmune response
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0042496Biological processdetection of diacyl bacterial lipopeptide
GO_0045429Biological processpositive regulation of nitric oxide biosynthetic process
GO_0032717Biological processnegative regulation of interleukin-8 production
GO_0042742Biological processdefense response to bacterium
GO_0007250Biological processactivation of NF-kappaB-inducing kinase activity
GO_0046209Biological processnitric oxide metabolic process
GO_1904646Biological processcellular response to amyloid-beta
GO_0140052Biological processcellular response to oxidised low-density lipoprotein particle stimulus
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0005794Cellular componentGolgi apparatus
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0035355Cellular componentToll-like receptor 2-Toll-like receptor 6 protein complex
GO_0038023Molecular functionsignaling receptor activity
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0001540Molecular functionamyloid-beta binding
GO_0005102Molecular functionsignaling receptor binding
GO_0035663Molecular functionToll-like receptor 2 binding
GO_0042802Molecular functionidentical protein binding
GO_0071723Molecular functionlipopeptide binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0061809Molecular functionNAD+ nucleotidase, cyclic ADP-ribose generating

IV. Literature review

[source]
Gene nameTLR6
Protein nameToll-like receptor 6 (CD antigen CD286)
Toll-like receptor 6
Toll-like receptor
Synonyms
DescriptionFUNCTION: Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides . In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway . Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 . In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion . .

AccessionsD1CS99
B6RFS7
Q9Y2C9
D1CS91
D1CS97
D6RAV7
ENST00000508254.5
B6CH44
D1CS98
B6CH42
ENST00000381950.2 [Q9Y2C9-1]
B6CH37
D1CS96
D1CS93
D1CS92
D1CSA0
ENST00000508254.6 [Q9Y2C9-1]
B6CH45