TRAF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035666Biological processTRIF-dependent toll-like receptor signaling pathway
GO_0002224Biological processtoll-like receptor signaling pathway
GO_0007165Biological processsignal transduction
GO_0051607Biological processdefense response to virus
GO_0032481Biological processpositive regulation of type I interferon production
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_0032648Biological processregulation of interferon-beta production
GO_0001817Biological processregulation of cytokine production
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0006915Biological processapoptotic process
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0050688Biological processregulation of defense response to virus
GO_0008063Biological processToll signaling pathway
GO_0030162Biological processregulation of proteolysis
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0000151Cellular componentubiquitin ligase complex
GO_0005739Cellular componentmitochondrion
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0098802Cellular componentplasma membrane signaling receptor complex
GO_0035631Cellular componentCD40 receptor complex
GO_1902554Cellular componentserine/threonine protein kinase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0031996Molecular functionthioesterase binding
GO_0019903Molecular functionprotein phosphatase binding
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008270Molecular functionzinc ion binding
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRAF3
Protein nameTNF receptor-associated factor (EC 2.3.2.27)
TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)
TNF receptor associated factor 3
SynonymsCAP-1
CRAF1
TRAFAMN
DescriptionFUNCTION: Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types . In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome . Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines. Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance . Acts also as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. .

AccessionsENST00000539721.5 [Q13114-2]
ENST00000558700.5
ENST00000699894.1 [Q13114-1]
ENST00000560371.5 [Q13114-1]
Q13114
H0YL25
ENST00000351691.10
H0YMI8
ENST00000560463.5
A6NHG8
ENST00000559734.1
H0YL26
ENST00000392745.8 [Q13114-1]
ENST00000699893.1