Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 11 studies | 31% ± 15% | |
macrophage | 11 studies | 30% ± 10% | |
B cell | 10 studies | 27% ± 9% | |
glutamatergic neuron | 9 studies | 42% ± 23% | |
microglial cell | 9 studies | 27% ± 9% | |
oligodendrocyte precursor cell | 7 studies | 28% ± 11% | |
endothelial cell | 6 studies | 33% ± 12% | |
myeloid cell | 6 studies | 26% ± 11% | |
adipocyte | 6 studies | 23% ± 4% | |
monocyte | 6 studies | 23% ± 5% | |
interneuron | 5 studies | 39% ± 21% | |
epithelial cell | 5 studies | 25% ± 8% | |
ciliated cell | 5 studies | 27% ± 9% | |
regulatory T cell | 5 studies | 19% ± 6% | |
GABAergic neuron | 5 studies | 45% ± 19% | |
T cell | 5 studies | 18% ± 3% | |
plasma cell | 4 studies | 45% ± 10% | |
fibroblast | 4 studies | 21% ± 4% | |
dendritic cell | 4 studies | 25% ± 5% | |
club cell | 4 studies | 19% ± 4% | |
oligodendrocyte | 4 studies | 27% ± 6% | |
naive B cell | 3 studies | 16% ± 1% | |
neuron | 3 studies | 28% ± 10% | |
GABAergic interneuron | 3 studies | 17% ± 1% | |
granule cell | 3 studies | 23% ± 6% | |
ON-bipolar cell | 3 studies | 23% ± 7% | |
memory B cell | 3 studies | 17% ± 2% | |
ependymal cell | 3 studies | 34% ± 8% | |
alveolar macrophage | 3 studies | 26% ± 6% | |
lymphocyte | 3 studies | 27% ± 8% | |
basal cell | 3 studies | 24% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1669.93 | 1445 / 1445 | 100% | 21.50 | 183 / 183 |
intestine | 100% | 2311.05 | 966 / 966 | 100% | 16.01 | 526 / 527 |
breast | 100% | 1509.59 | 459 / 459 | 99% | 14.60 | 1112 / 1118 |
lung | 99% | 2033.30 | 575 / 578 | 100% | 17.60 | 1153 / 1155 |
brain | 100% | 2971.68 | 2640 / 2642 | 99% | 18.79 | 700 / 705 |
prostate | 100% | 1866.77 | 245 / 245 | 99% | 11.87 | 498 / 502 |
skin | 100% | 1865.37 | 1807 / 1809 | 99% | 16.99 | 468 / 472 |
thymus | 100% | 1715.24 | 652 / 653 | 99% | 13.44 | 600 / 605 |
uterus | 100% | 1840.03 | 170 / 170 | 99% | 16.17 | 454 / 459 |
bladder | 100% | 1942.48 | 21 / 21 | 99% | 13.19 | 497 / 504 |
kidney | 100% | 1684.40 | 89 / 89 | 99% | 11.68 | 888 / 901 |
ovary | 100% | 1072.37 | 180 / 180 | 98% | 14.79 | 423 / 430 |
stomach | 98% | 1142.52 | 351 / 359 | 100% | 15.86 | 286 / 286 |
pancreas | 92% | 771.81 | 301 / 328 | 98% | 14.53 | 175 / 178 |
adrenal gland | 100% | 1359.36 | 258 / 258 | 87% | 7.95 | 199 / 230 |
liver | 96% | 782.72 | 218 / 226 | 75% | 5.55 | 305 / 406 |
adipose | 100% | 1749.07 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 35.08 | 29 / 29 |
spleen | 100% | 3442.46 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.42 | 1 / 1 |
blood vessel | 99% | 1369.49 | 1327 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 23.16 | 44 / 45 |
eye | 0% | 0 | 0 / 0 | 94% | 13.88 | 75 / 80 |
heart | 93% | 1017.01 | 801 / 861 | 0% | 0 | 0 / 0 |
muscle | 93% | 835.41 | 745 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 84% | 2998.77 | 784 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0035666 | Biological process | TRIF-dependent toll-like receptor signaling pathway |
GO_0002224 | Biological process | toll-like receptor signaling pathway |
GO_0007165 | Biological process | signal transduction |
GO_0051607 | Biological process | defense response to virus |
GO_0032481 | Biological process | positive regulation of type I interferon production |
GO_0032088 | Biological process | negative regulation of NF-kappaB transcription factor activity |
GO_0060337 | Biological process | type I interferon-mediated signaling pathway |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_0032648 | Biological process | regulation of interferon-beta production |
GO_0001817 | Biological process | regulation of cytokine production |
GO_0034142 | Biological process | toll-like receptor 4 signaling pathway |
GO_0070534 | Biological process | protein K63-linked ubiquitination |
GO_0006915 | Biological process | apoptotic process |
GO_0043122 | Biological process | regulation of canonical NF-kappaB signal transduction |
GO_0050688 | Biological process | regulation of defense response to virus |
GO_0008063 | Biological process | Toll signaling pathway |
GO_0030162 | Biological process | regulation of proteolysis |
GO_0033209 | Biological process | tumor necrosis factor-mediated signaling pathway |
GO_0000151 | Cellular component | ubiquitin ligase complex |
GO_0005739 | Cellular component | mitochondrion |
GO_0009898 | Cellular component | cytoplasmic side of plasma membrane |
GO_0098802 | Cellular component | plasma membrane signaling receptor complex |
GO_0035631 | Cellular component | CD40 receptor complex |
GO_1902554 | Cellular component | serine/threonine protein kinase complex |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0010008 | Cellular component | endosome membrane |
GO_0005768 | Cellular component | endosome |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0031996 | Molecular function | thioesterase binding |
GO_0019903 | Molecular function | protein phosphatase binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0005164 | Molecular function | tumor necrosis factor receptor binding |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | TRAF3 |
Protein name | TNF receptor-associated factor (EC 2.3.2.27) TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3) TNF receptor associated factor 3 |
Synonyms | CAP-1 CRAF1 TRAFAMN |
Description | FUNCTION: Cytoplasmic E3 ubiquitin ligase that regulates various signaling pathways, such as the NF-kappa-B, mitogen-activated protein kinase (MAPK) and interferon regulatory factor (IRF) pathways, and thus controls a lot of biological processes in both immune and non-immune cell types . In TLR and RLR signaling pathways, acts as an E3 ubiquitin ligase promoting the synthesis of 'Lys-63'-linked polyubiquitin chains on several substrates such as ASC that lead to the activation of the type I interferon response or the inflammasome . Following the activation of certain TLRs such as TLR4, acts as a negative NF-kappa-B regulator, possibly to avoid unregulated inflammatory response, and its degradation via 'Lys-48'-linked polyubiquitination is required for MAPK activation and production of inflammatory cytokines. Alternatively, when TLR4 orchestrates bacterial expulsion, TRAF3 undergoes 'Lys-33'-linked polyubiquitination and subsequently binds to RALGDS, mobilizing the exocyst complex to rapidly expel intracellular bacteria back for clearance . Acts also as a constitutive negative regulator of the alternative NF-kappa-B pathway, which controls B-cell survival and lymphoid organ development. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. . |
Accessions | ENST00000539721.5 [Q13114-2] ENST00000558700.5 ENST00000699894.1 [Q13114-1] ENST00000560371.5 [Q13114-1] Q13114 H0YL25 ENST00000351691.10 H0YMI8 ENST00000560463.5 A6NHG8 ENST00000559734.1 H0YL26 ENST00000392745.8 [Q13114-1] ENST00000699893.1 |