STAT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043434Biological processresponse to peptide hormone
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0051607Biological processdefense response to virus
GO_0001932Biological processregulation of protein phosphorylation
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0090140Biological processregulation of mitochondrial fission
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0042127Biological processregulation of cell population proliferation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006952Biological processdefense response
GO_0070721Cellular componentISGF3 complex
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0044389Molecular functionubiquitin-like protein ligase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSTAT2
Protein nameSTAT2 protein
Signal transducer and activator of transcription 2 (p113)
Signal transducer and activator of transcription
Signal transducer and activator of transcription 2
Signal transducer and activator of transcription 2 (cDNA, FLJ79415, highly similar to Signal transducer and activator of transcription 2)
SynonymshCG_24995
DescriptionFUNCTION: Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state . In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs . Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively . .

AccessionsR9QE71
R9QE65
R9QDZ0
B4DHE0
R9QG81
ENST00000418572.7
R9QE63
R9QG91
A0A494C164
R9QG88
ENST00000314128.9 [P52630-3]
A0A494C1L3
ENST00000698186.1
R9QF97
G3V319
R9QDY3
R9QDW5
R9QE53
R9QDY7
ENST00000651301.1
ENST00000652398.1
R9QF99
ENST00000557235.5 [P52630-4]
R9QDW3
R9QE44
A0A8V8TLG8
R9QF58
R9QGC0
ENST00000652741.1
ENST00000698180.1
R9QFA6
ENST00000651915.1
A0A8V8TLJ4
ENST00000652624.1
R9QFC5
B4DLC8
ENST00000650805.1
ENST00000698193.1
R9QFA2
ENST00000698192.1 [P52630-3]
ENST00000555646.1
A0A494C0B5
A0JLQ9
R9QG79
P52630