TANK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000158Biological processpositive regulation of ubiquitin-specific protease activity
GO_0007165Biological processsignal transduction
GO_0051607Biological processdefense response to virus
GO_0006974Biological processDNA damage response
GO_0071347Biological processcellular response to interleukin-1
GO_0032481Biological processpositive regulation of type I interferon production
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_1903003Biological processpositive regulation of protein deubiquitination
GO_0071479Biological processcellular response to ionizing radiation
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0032991Cellular componentprotein-containing complex
GO_1902554Cellular componentserine/threonine protein kinase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0035800Molecular functiondeubiquitinase activator activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0140678Molecular functionmolecular function inhibitor activity

IV. Literature review

[source]
Gene nameTANK
Protein nameTRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)
Uncharacterized protein TANK
TRAF family member associated NFKB activator
TANK protein
SynonymsTRAF2
ITRAF
DescriptionFUNCTION: Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage . Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage . Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage . May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. .

AccessionsENST00000392749.7 [Q92844-1]
E7EWR8
ENST00000432692.6
ENST00000432002.5
ENST00000441987.5
Q4ZG76
E7ENY2
ENST00000402568.5
ENST00000406287.5
Q53TI5
H7C3L4
ENST00000405852.5
E7EVA2
H7BZ28
E7EQA9
ENST00000456358.5
E7EW82
E7EMT6
E7EM55
ENST00000457887.5
ENST00000437623.1
ENST00000440506.5
Q6NW12
ENST00000439442.1
ENST00000259075.6 [Q92844-1]
ENST00000403609.1 [Q92844-3]
E9PEK1
Q92844
ENST00000429217.5
E7EV32
E7ERM9