JAK1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	48 studies	42% ± 16%	Explore
natural killer cell	47 studies	60% ± 18%	Explore
B cell	42 studies	43% ± 11%	Explore
fibroblast	39 studies	36% ± 16%	Explore
CD8-positive, alpha-beta T cell	38 studies	42% ± 14%	Explore
T cell	36 studies	40% ± 15%	Explore
macrophage	35 studies	34% ± 12%	Explore
pericyte	35 studies	43% ± 17%	Explore
CD4-positive, alpha-beta T cell	34 studies	45% ± 12%	Explore
smooth muscle cell	30 studies	32% ± 10%	Explore
regulatory T cell	28 studies	54% ± 14%	Explore
classical monocyte	26 studies	35% ± 13%	Explore
conventional dendritic cell	26 studies	36% ± 15%	Explore
dendritic cell	24 studies	46% ± 22%	Explore
non-classical monocyte	24 studies	42% ± 14%	Explore
mature NK T cell	23 studies	52% ± 16%	Explore
endothelial cell of lymphatic vessel	22 studies	36% ± 13%	Explore
monocyte	21 studies	34% ± 11%	Explore
memory B cell	20 studies	51% ± 11%	Explore
naive B cell	20 studies	45% ± 12%	Explore
gamma-delta T cell	19 studies	56% ± 15%	Explore
plasmacytoid dendritic cell	19 studies	45% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	47% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	72% ± 15%	Explore
mucosal invariant T cell	16 studies	56% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	72% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	50% ± 13%	Explore
ciliated cell	15 studies	30% ± 13%	Explore
astrocyte	15 studies	44% ± 21%	Explore
capillary endothelial cell	15 studies	38% ± 11%	Explore
mast cell	14 studies	25% ± 11%	Explore
epithelial cell	14 studies	39% ± 21%	Explore
plasma cell	13 studies	29% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	53% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	52% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	56% ± 12%	Explore
basal cell	13 studies	33% ± 15%	Explore
connective tissue cell	13 studies	33% ± 10%	Explore
endothelial cell of artery	13 studies	36% ± 9%	Explore
vein endothelial cell	13 studies	40% ± 15%	Explore
microglial cell	13 studies	40% ± 13%	Explore
leukocyte	12 studies	43% ± 17%	Explore
oligodendrocyte precursor cell	12 studies	36% ± 21%	Explore
myofibroblast cell	12 studies	29% ± 11%	Explore
myeloid cell	12 studies	35% ± 14%	Explore
endothelial cell of vascular tree	12 studies	39% ± 12%	Explore
type II pneumocyte	10 studies	36% ± 12%	Explore
platelet	10 studies	30% ± 8%	Explore
GABAergic neuron	10 studies	47% ± 22%	Explore
glutamatergic neuron	10 studies	46% ± 26%	Explore
oligodendrocyte	10 studies	39% ± 18%	Explore
innate lymphoid cell	9 studies	54% ± 19%	Explore
plasmablast	9 studies	40% ± 17%	Explore
secretory cell	9 studies	33% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	44% ± 12%	Explore
abnormal cell	8 studies	29% ± 14%	Explore
neuron	8 studies	31% ± 14%	Explore
adipocyte	8 studies	37% ± 14%	Explore
club cell	7 studies	29% ± 9%	Explore
neutrophil	7 studies	25% ± 4%	Explore
T follicular helper cell	7 studies	48% ± 13%	Explore
type I pneumocyte	6 studies	23% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	45% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	43% ± 12%	Explore
mononuclear phagocyte	6 studies	34% ± 9%	Explore
interneuron	6 studies	54% ± 31%	Explore
lymphocyte	6 studies	53% ± 19%	Explore
precursor B cell	6 studies	46% ± 9%	Explore
immature B cell	6 studies	50% ± 7%	Explore
retinal cone cell	6 studies	25% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	56% ± 11%	Explore
goblet cell	6 studies	31% ± 23%	Explore
alveolar macrophage	5 studies	29% ± 10%	Explore
CD4-positive helper T cell	5 studies	44% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	47% ± 7%	Explore
hematopoietic precursor cell	5 studies	30% ± 12%	Explore
exhausted T cell	5 studies	53% ± 11%	Explore
respiratory goblet cell	5 studies	30% ± 10%	Explore
retinal ganglion cell	5 studies	78% ± 13%	Explore
hematopoietic stem cell	5 studies	35% ± 6%	Explore
pro-B cell	5 studies	42% ± 11%	Explore
brush cell	5 studies	34% ± 15%	Explore
T-helper 17 cell	5 studies	44% ± 15%	Explore
amacrine cell	5 studies	30% ± 10%	Explore
retina horizontal cell	5 studies	22% ± 7%	Explore
mesothelial cell	5 studies	30% ± 16%	Explore
Mueller cell	5 studies	31% ± 12%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	35% ± 11%	Explore
pancreatic A cell	4 studies	44% ± 17%	Explore
progenitor cell	4 studies	26% ± 14%	Explore
renal alpha-intercalated cell	4 studies	24% ± 10%	Explore
glial cell	4 studies	23% ± 3%	Explore
kidney loop of Henle epithelial cell	4 studies	23% ± 6%	Explore
megakaryocyte	4 studies	46% ± 25%	Explore
group 3 innate lymphoid cell	4 studies	68% ± 11%	Explore
retinal rod cell	4 studies	31% ± 12%	Explore
cardiac muscle cell	4 studies	33% ± 11%	Explore
OFF-bipolar cell	4 studies	49% ± 22%	Explore
ON-bipolar cell	4 studies	47% ± 28%	Explore
intermediate monocyte	4 studies	47% ± 25%	Explore
IgA plasma cell	4 studies	22% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	32% ± 11%	Explore
enteroendocrine cell	4 studies	27% ± 7%	Explore
double negative thymocyte	4 studies	54% ± 16%	Explore
ionocyte	3 studies	35% ± 2%	Explore
precursor cell	3 studies	35% ± 3%	Explore
squamous epithelial cell	3 studies	44% ± 22%	Explore
type B pancreatic cell	3 studies	59% ± 16%	Explore
monocyte-derived dendritic cell	3 studies	41% ± 19%	Explore
glomerular endothelial cell	3 studies	31% ± 1%	Explore
GABAergic interneuron	3 studies	46% ± 10%	Explore
retinal bipolar neuron	3 studies	20% ± 5%	Explore
retinal pigment epithelial cell	3 studies	45% ± 31%	Explore
tissue-resident macrophage	3 studies	31% ± 9%	Explore
GABAergic amacrine cell	3 studies	39% ± 12%	Explore
glycinergic amacrine cell	3 studies	37% ± 10%	Explore
rod bipolar cell	3 studies	39% ± 18%	Explore
germinal center B cell	3 studies	50% ± 10%	Explore
IgG plasma cell	3 studies	22% ± 4%	Explore
cholangiocyte	3 studies	41% ± 23%	Explore
endothelial cell of sinusoid	3 studies	40% ± 20%	Explore
hepatocyte	3 studies	48% ± 28%	Explore
muscle cell	3 studies	49% ± 23%	Explore
pancreatic ductal cell	3 studies	58% ± 25%	Explore
neural progenitor cell	3 studies	36% ± 10%	Explore
ependymal cell	3 studies	39% ± 7%	Explore
granulocyte	3 studies	38% ± 15%	Explore
adventitial cell	3 studies	37% ± 10%	Explore
granule cell	3 studies	24% ± 5%	Explore
T-helper 1 cell	3 studies	54% ± 15%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	50% ± 14%	Explore
double-positive, alpha-beta thymocyte	3 studies	53% ± 21%	Explore
myoepithelial cell	3 studies	24% ± 7%	Explore
mural cell	3 studies	61% ± 11%	Explore
epithelial cell of proximal tubule	3 studies	26% ± 9%	Explore
erythrocyte	3 studies	34% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	48% ± 12%	Explore
lung	18 studies	33% ± 12%	Explore
brain	15 studies	40% ± 23%	Explore
intestine	9 studies	25% ± 7%	Explore
eye	9 studies	32% ± 19%	Explore
kidney	7 studies	32% ± 10%	Explore
liver	6 studies	32% ± 12%	Explore
heart	5 studies	29% ± 11%	Explore
bone marrow	4 studies	40% ± 14%	Explore
uterus	4 studies	37% ± 10%	Explore
lymph node	4 studies	45% ± 7%	Explore
breast	4 studies	32% ± 9%	Explore
prostate	4 studies	23% ± 7%	Explore
adipose	4 studies	40% ± 7%	Explore
pancreas	3 studies	56% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	9018.96	1445 / 1445	100%	53.77	183 / 183
lung	100%	15466.49	578 / 578	100%	44.87	1153 / 1155
stomach	100%	7404.85	359 / 359	100%	47.72	285 / 286
breast	100%	15872.87	459 / 459	100%	62.00	1114 / 1118
thymus	100%	10355.71	653 / 653	99%	51.02	600 / 605
kidney	100%	7985.08	89 / 89	99%	72.40	892 / 901
skin	100%	14788.31	1808 / 1809	99%	46.43	467 / 472
intestine	100%	11044.55	966 / 966	99%	43.68	520 / 527
bladder	100%	11798.48	21 / 21	98%	37.16	496 / 504
uterus	100%	11636.84	170 / 170	98%	38.43	451 / 459
brain	98%	5773.36	2578 / 2642	100%	51.87	705 / 705
prostate	100%	7459.71	244 / 245	97%	30.13	488 / 502
pancreas	97%	5761.34	319 / 328	99%	54.43	176 / 178
ovary	100%	12944.07	180 / 180	96%	27.51	412 / 430
liver	98%	4698.68	221 / 226	93%	29.40	378 / 406
adrenal gland	100%	7993.11	258 / 258	90%	23.39	208 / 230
adipose	100%	18451.27	1204 / 1204	0%	0	0 / 0
blood vessel	100%	11877.75	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	66.91	29 / 29
muscle	100%	12197.68	803 / 803	0%	0	0 / 0
spleen	100%	15546.64	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	11.95	1 / 1
peripheral blood	99%	11709.33	917 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	43.92	44 / 45
heart	96%	7588.71	823 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	93%	27.57	74 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0038110	Biological process	interleukin-2-mediated signaling pathway
GO_0038113	Biological process	interleukin-9-mediated signaling pathway
GO_0007260	Biological process	tyrosine phosphorylation of STAT protein
GO_0035723	Biological process	interleukin-15-mediated signaling pathway
GO_0060397	Biological process	growth hormone receptor signaling pathway via JAK-STAT
GO_0060333	Biological process	type II interferon-mediated signaling pathway
GO_1903672	Biological process	positive regulation of sprouting angiogenesis
GO_0038154	Biological process	interleukin-11-mediated signaling pathway
GO_0140105	Biological process	interleukin-10-mediated signaling pathway
GO_0035771	Biological process	interleukin-4-mediated signaling pathway
GO_0098586	Biological process	cellular response to virus
GO_0060337	Biological process	type I interferon-mediated signaling pathway
GO_0070102	Biological process	interleukin-6-mediated signaling pathway
GO_0035556	Biological process	intracellular signal transduction
GO_0072540	Biological process	T-helper 17 cell lineage commitment
GO_0030154	Biological process	cell differentiation
GO_0046677	Biological process	response to antibiotic
GO_0034112	Biological process	positive regulation of homotypic cell-cell adhesion
GO_0006468	Biological process	protein phosphorylation
GO_0150105	Biological process	protein localization to cell-cell junction
GO_0007259	Biological process	cell surface receptor signaling pathway via JAK-STAT
GO_0038196	Biological process	type III interferon-mediated signaling pathway
GO_1900182	Biological process	positive regulation of protein localization to nucleus
GO_0005856	Cellular component	cytoskeleton
GO_0005886	Cellular component	plasma membrane
GO_0031234	Cellular component	extrinsic component of cytoplasmic side of plasma membrane
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0005925	Cellular component	focal adhesion
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005768	Cellular component	endosome
GO_0005634	Cellular component	nucleus
GO_0031730	Molecular function	CCR5 chemokine receptor binding
GO_0004715	Molecular function	non-membrane spanning protein tyrosine kinase activity
GO_0019903	Molecular function	protein phosphatase binding
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0046872	Molecular function	metal ion binding
GO_0005131	Molecular function	growth hormone receptor binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	JAK1
Protein name	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) Tyrosine-protein kinase JAK1 JAK1 protein Tyrosine-protein kinase (EC 2.7.10.2) Janus kinase 1
Synonyms	JAK1A JAK1B
Description	FUNCTION: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway . Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor . Kinase partner for the type I interferon receptor IFNAR2 . In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins . Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors . .
Accessions	A0A8V8TPG3 ENST00000342505.5 ENST00000672574.2 A0A0A0N0M2 ENST00000699310.1 ENST00000699313.1 ENST00000671746.2 A0A8V8TN56 Q4LDX3 ENST00000699262.1 ENST00000672247.2 ENST00000671954.2 ENST00000672434.2 ENST00000699260.1 A0A5F9ZHW0 ENST00000672179.2 A0A8V8TMY8 ENST00000671929.2 ENST00000699311.1 A0A5F9ZH07 Q8IV82 ENST00000673046.1 ENST00000699261.1 A0A5F9ZHN8 A0A5F9ZHI1 ENST00000672751.2 ENST00000673246.2 ENST00000699314.1 ENST00000699263.1 A0A8V8TPQ9 Q6P669 ENST00000672099.1 A0A5F9ZI01 P23458 A0A5F9ZH73 A0A5F9ZI39 ENST00000672751.1 A0A5F9ZHK2 Q0VGA4 A0A8V8TN11 ENST00000673254.1 ENST00000673220.1 ENST00000699259.1 ENST00000699312.1

JAK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review