interleukin-2-mediated signaling pathway

I. Involved cell types

Genes
Cell types
No. of supported studies
Group 1
IL2RAIL2RBIL2RGJAK1
regulatory T cell
5 studies
Group 2
STAT3JAK3
myeloid cellregulatory T cellCD4-positive, alpha-beta T cellnaive thymus-derived CD8-positive, alpha-beta T cell
18 studies
Group 3
STAT5A
adipocytemegakaryocyte-erythroid progenitor cellcommon myeloid progenitor
12 studies

II. Involved cell-cell interactions

[source]
Interactors
Protein name
Directionality
Classification
1IL2-IL2RA+IL2RB+IL2RGIL2_HUMAN - Ligand-ReceptorSignaling by Interleukin
2IL2-IL2RB+IL2RGIL2_HUMAN - Ligand-ReceptorSignaling by Interleukin

III. Literature review

[source]
Nameinterleukin-2-mediated signaling pathway
IDGO_0038110
collection_id

Biological process

Exact synonym

IL-2-mediated signaling pathway, interleukin-2-mediated signalling pathway

Description

The series of molecular signals initiated by interleukin-2 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

External URL
Genes
STAT5AIL2RAil2-receptor_humanSTAT3JAK3JAK1IL2RGIL2RBIL2