Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| lung | 19 studies | 35% ± 9% | |
| peripheral blood | 17 studies | 31% ± 10% | |
| brain | 13 studies | 29% ± 13% | |
| intestine | 10 studies | 26% ± 12% | |
| eye | 9 studies | 35% ± 13% | |
| kidney | 8 studies | 29% ± 8% | |
| liver | 6 studies | 33% ± 12% | |
| heart | 5 studies | 35% ± 13% | |
| uterus | 5 studies | 39% ± 14% | |
| lymph node | 5 studies | 34% ± 8% | |
| breast | 5 studies | 38% ± 8% | |
| adipose | 4 studies | 43% ± 16% | |
| bone marrow | 3 studies | 28% ± 8% | |
| prostate | 3 studies | 27% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 26508.18 | 578 / 578 | 100% | 94.45 | 1155 / 1155 |
| esophagus | 100% | 18373.21 | 1444 / 1445 | 100% | 94.76 | 183 / 183 |
| prostate | 100% | 16402.14 | 245 / 245 | 100% | 81.44 | 501 / 502 |
| uterus | 100% | 16246.01 | 170 / 170 | 100% | 74.53 | 458 / 459 |
| breast | 100% | 21546.19 | 459 / 459 | 100% | 109.67 | 1115 / 1118 |
| ovary | 100% | 15489.29 | 180 / 180 | 100% | 63.17 | 428 / 430 |
| stomach | 99% | 12567.21 | 357 / 359 | 100% | 73.02 | 286 / 286 |
| intestine | 100% | 16927.65 | 966 / 966 | 99% | 65.32 | 524 / 527 |
| thymus | 100% | 16562.16 | 652 / 653 | 99% | 67.21 | 600 / 605 |
| skin | 100% | 14537.34 | 1809 / 1809 | 99% | 67.25 | 467 / 472 |
| bladder | 100% | 18580.81 | 21 / 21 | 98% | 59.94 | 496 / 504 |
| kidney | 100% | 13813.67 | 89 / 89 | 98% | 64.97 | 879 / 901 |
| liver | 100% | 18444.60 | 226 / 226 | 97% | 42.87 | 392 / 406 |
| pancreas | 96% | 9357.56 | 316 / 328 | 100% | 72.04 | 178 / 178 |
| adrenal gland | 100% | 15798.80 | 258 / 258 | 92% | 37.11 | 212 / 230 |
| brain | 87% | 5037.09 | 2302 / 2642 | 100% | 65.41 | 705 / 705 |
| adipose | 100% | 23448.99 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 21327.87 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 77.90 | 29 / 29 |
| muscle | 100% | 16505.36 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 16833.05 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 114.08 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 15.38 | 1 / 1 |
| peripheral blood | 99% | 20011.90 | 921 / 929 | 0% | 0 | 0 / 0 |
| heart | 97% | 13963.25 | 836 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 90% | 41.52 | 72 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0097009 | Biological process | energy homeostasis |
| GO_0001754 | Biological process | eye photoreceptor cell differentiation |
| GO_0006954 | Biological process | inflammatory response |
| GO_0008283 | Biological process | cell population proliferation |
| GO_2000635 | Biological process | negative regulation of primary miRNA processing |
| GO_1905564 | Biological process | positive regulation of vascular endothelial cell proliferation |
| GO_0032870 | Biological process | cellular response to hormone stimulus |
| GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
| GO_0050728 | Biological process | negative regulation of inflammatory response |
| GO_1902895 | Biological process | positive regulation of miRNA transcription |
| GO_0042755 | Biological process | eating behavior |
| GO_0043491 | Biological process | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0042789 | Biological process | mRNA transcription by RNA polymerase II |
| GO_0001659 | Biological process | temperature homeostasis |
| GO_0051726 | Biological process | regulation of cell cycle |
| GO_0072538 | Biological process | T-helper 17 type immune response |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0043434 | Biological process | response to peptide hormone |
| GO_0097696 | Biological process | cell surface receptor signaling pathway via STAT |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0060221 | Biological process | retinal rod cell differentiation |
| GO_0007165 | Biological process | signal transduction |
| GO_0060396 | Biological process | growth hormone receptor signaling pathway |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0060259 | Biological process | regulation of feeding behavior |
| GO_0048708 | Biological process | astrocyte differentiation |
| GO_1900017 | Biological process | positive regulation of cytokine production involved in inflammatory response |
| GO_0045820 | Biological process | negative regulation of glycolytic process |
| GO_0006606 | Biological process | protein import into nucleus |
| GO_0032757 | Biological process | positive regulation of interleukin-8 production |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0045648 | Biological process | positive regulation of erythrocyte differentiation |
| GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
| GO_0007259 | Biological process | cell surface receptor signaling pathway via JAK-STAT |
| GO_0007399 | Biological process | nervous system development |
| GO_0032755 | Biological process | positive regulation of interleukin-6 production |
| GO_2001223 | Biological process | negative regulation of neuron migration |
| GO_0032355 | Biological process | response to estradiol |
| GO_0038113 | Biological process | interleukin-9-mediated signaling pathway |
| GO_0097398 | Biological process | cellular response to interleukin-17 |
| GO_0060397 | Biological process | growth hormone receptor signaling pathway via JAK-STAT |
| GO_0030522 | Biological process | intracellular receptor signaling pathway |
| GO_0032731 | Biological process | positive regulation of interleukin-1 beta production |
| GO_0044320 | Biological process | cellular response to leptin stimulus |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0033210 | Biological process | leptin-mediated signaling pathway |
| GO_0072540 | Biological process | T-helper 17 cell lineage commitment |
| GO_0019953 | Biological process | sexual reproduction |
| GO_0010575 | Biological process | positive regulation of vascular endothelial growth factor production |
| GO_0016310 | Biological process | phosphorylation |
| GO_0042127 | Biological process | regulation of cell population proliferation |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0035019 | Biological process | somatic stem cell population maintenance |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0038110 | Biological process | interleukin-2-mediated signaling pathway |
| GO_0035723 | Biological process | interleukin-15-mediated signaling pathway |
| GO_0044321 | Biological process | response to leptin |
| GO_0060019 | Biological process | radial glial cell differentiation |
| GO_0038154 | Biological process | interleukin-11-mediated signaling pathway |
| GO_0032733 | Biological process | positive regulation of interleukin-10 production |
| GO_0040014 | Biological process | regulation of multicellular organism growth |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_1904685 | Biological process | positive regulation of metalloendopeptidase activity |
| GO_0140105 | Biological process | interleukin-10-mediated signaling pathway |
| GO_0070102 | Biological process | interleukin-6-mediated signaling pathway |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0030154 | Biological process | cell differentiation |
| GO_2000737 | Biological process | negative regulation of stem cell differentiation |
| GO_0010507 | Biological process | negative regulation of autophagy |
| GO_0106015 | Biological process | negative regulation of inflammatory response to wounding |
| GO_0045747 | Biological process | positive regulation of Notch signaling pathway |
| GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
| GO_0042593 | Biological process | glucose homeostasis |
| GO_0006952 | Biological process | defense response |
| GO_0005634 | Cellular component | nucleus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0090575 | Cellular component | RNA polymerase II transcription regulator complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0140297 | Molecular function | DNA-binding transcription factor binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0031490 | Molecular function | chromatin DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_0004879 | Molecular function | nuclear receptor activity |
| GO_0035591 | Molecular function | signaling adaptor activity |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0106222 | Molecular function | lncRNA binding |
| GO_0070878 | Molecular function | primary miRNA binding |
| GO_0140610 | Molecular function | RNA sequestering activity |
| GO_0046983 | Molecular function | protein dimerization activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0003677 | Molecular function | DNA binding |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0019903 | Molecular function | protein phosphatase binding |
| GO_0019901 | Molecular function | protein kinase binding |
| Gene name | STAT3 |
| Protein name | Signal transducer and activator of transcription 3 STAT3 Signal transducer and activator of transcription 3 (Acute-phase response factor) Signal transducer and activator of transcription |
| Synonyms | APRF |
| Description | FUNCTION: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors . Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene . May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 . Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes . Activated by IL31 through IL31RA . Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation . Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 . Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation . Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity . Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). . |
| Accessions | ENST00000678905.1 G8JLH9 Q9BXH2 A0A7I2V3V0 A0A7I2YQD2 A0A7I2V552 ENST00000679166.1 ENST00000585517.5 [P40763-3] ENST00000678674.1 ENST00000678044.1 [P40763-1] ENST00000677479.1 A0A7I2V5N9 ENST00000264657.10 [P40763-1] ENST00000678043.1 A0A7I2V4R3 ENST00000679185.1 ENST00000678827.1 [P40763-3] ENST00000678913.1 ENST00000677271.1 A0A7I2V4R2 ENST00000404395.3 [P40763-2] ENST00000677442.1 ENST00000678445.1 ENST00000678792.1 P40763 A0A7I2V2G1 ENST00000677308.1 ENST00000679014.1 [P40763-2] ENST00000677030.1 [P40763-3] ENST00000678572.1 A0A7I2YQI1 ENST00000677820.1 A0A7I2YQR5 B5BTZ6 ENST00000678960.1 [P40763-1] A0A7I2V395 A0A7I2V444 A0A7I2V2T1 ENST00000678535.1 ENST00000677723.1 [P40763-2] A0A7I2V4F6 ENST00000588969.5 [P40763-1] ENST00000678906.1 [P40763-1] ENST00000677152.1 ENST00000676636.1 ENST00000678048.1 ENST00000677002.1 ENST00000389272.7 ENST00000677603.1 A0A7I2V4C8 ENST00000677421.1 |
