Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| regulatory T cell | 24 studies | 36% ± 20% | |
| macrophage | 5 studies | 23% ± 3% | |
| CD4-positive, alpha-beta T cell | 4 studies | 54% ± 22% | |
| CD8-positive, alpha-beta T cell | 4 studies | 52% ± 20% |
Insufficient scRNA-seq data for expression of IL2RA at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 99% | 257.10 | 575 / 578 | 94% | 8.11 | 1084 / 1155 |
| intestine | 85% | 304.22 | 819 / 966 | 80% | 4.54 | 424 / 527 |
| thymus | 94% | 187.24 | 611 / 653 | 64% | 2.12 | 388 / 605 |
| esophagus | 62% | 71.06 | 898 / 1445 | 88% | 4.77 | 161 / 183 |
| stomach | 63% | 63.57 | 226 / 359 | 85% | 5.27 | 242 / 286 |
| breast | 77% | 92.78 | 354 / 459 | 70% | 3.52 | 784 / 1118 |
| bladder | 62% | 51.52 | 13 / 21 | 75% | 4.92 | 378 / 504 |
| kidney | 69% | 78.28 | 61 / 89 | 59% | 2.76 | 533 / 901 |
| adrenal gland | 83% | 180.05 | 215 / 258 | 31% | 1.17 | 72 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 54.53 | 29 / 29 |
| spleen | 100% | 995.70 | 241 / 241 | 0% | 0 | 0 / 0 |
| uterus | 23% | 18.52 | 39 / 170 | 74% | 3.58 | 339 / 459 |
| peripheral blood | 95% | 350.21 | 884 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 8.77 | 42 / 45 |
| prostate | 57% | 56.94 | 140 / 245 | 35% | 0.82 | 175 / 502 |
| skin | 17% | 8.97 | 302 / 1809 | 75% | 4.59 | 354 / 472 |
| pancreas | 8% | 4.72 | 27 / 328 | 83% | 7.04 | 147 / 178 |
| ovary | 19% | 13.21 | 35 / 180 | 60% | 1.62 | 256 / 430 |
| adipose | 74% | 211.86 | 891 / 1204 | 0% | 0 | 0 / 0 |
| liver | 29% | 29.28 | 65 / 226 | 27% | 0.90 | 109 / 406 |
| blood vessel | 49% | 113.29 | 652 / 1335 | 0% | 0 | 0 / 0 |
| heart | 42% | 35.72 | 358 / 861 | 0% | 0 | 0 / 0 |
| brain | 3% | 2.34 | 83 / 2642 | 22% | 1.86 | 152 / 705 |
| eye | 0% | 0 | 0 / 0 | 14% | 0.32 | 11 / 80 |
| muscle | 5% | 2.57 | 41 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042104 | Biological process | positive regulation of activated T cell proliferation |
| GO_0038110 | Biological process | interleukin-2-mediated signaling pathway |
| GO_0006954 | Biological process | inflammatory response |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0045582 | Biological process | positive regulation of T cell differentiation |
| GO_0002437 | Biological process | inflammatory response to antigenic stimulus |
| GO_0046013 | Biological process | regulation of T cell homeostatic proliferation |
| GO_0002664 | Biological process | regulation of T cell tolerance induction |
| GO_0006955 | Biological process | immune response |
| GO_0050728 | Biological process | negative regulation of inflammatory response |
| GO_0042130 | Biological process | negative regulation of T cell proliferation |
| GO_0006924 | Biological process | activation-induced cell death of T cells |
| GO_0050798 | Biological process | activated T cell proliferation |
| GO_0006915 | Biological process | apoptotic process |
| GO_2000561 | Biological process | regulation of CD4-positive, alpha-beta T cell proliferation |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0005893 | Cellular component | interleukin-2 receptor complex |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0019976 | Molecular function | interleukin-2 binding |
| GO_0004911 | Molecular function | interleukin-2 receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | IL2RA |
| Protein name | Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25) Interleukin-2 receptor subunit alpha |
| Synonyms | hCG_23482 |
| Description | FUNCTION: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. . FUNCTION: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. . FUNCTION: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. . FUNCTION: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. . FUNCTION: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. . |
| Accessions | H0Y5Z0 ENST00000447847.2 Q5W005 P01589 ENST00000379954.5 ENST00000256876.10 ENST00000379959.8 A0A8V8TMM2 Q5W006 ENST00000697424.1 |
