JAK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043029Biological processT cell homeostasis
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0038110Biological processinterleukin-2-mediated signaling pathway
GO_0038113Biological processinterleukin-9-mediated signaling pathway
GO_0007260Biological processtyrosine phosphorylation of STAT protein
GO_0035723Biological processinterleukin-15-mediated signaling pathway
GO_0002731Biological processnegative regulation of dendritic cell cytokine production
GO_0045087Biological processinnate immune response
GO_0060397Biological processgrowth hormone receptor signaling pathway via JAK-STAT
GO_0007167Biological processenzyme-linked receptor protein signaling pathway
GO_0050868Biological processnegative regulation of T cell activation
GO_0070232Biological processregulation of T cell apoptotic process
GO_0032695Biological processnegative regulation of interleukin-12 production
GO_0071104Biological processresponse to interleukin-9
GO_0032693Biological processnegative regulation of interleukin-10 production
GO_0035771Biological processinterleukin-4-mediated signaling pathway
GO_0002250Biological processadaptive immune response
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0035556Biological processintracellular signal transduction
GO_0042981Biological processregulation of apoptotic process
GO_0070669Biological processresponse to interleukin-2
GO_0030154Biological processcell differentiation
GO_0046425Biological processregulation of receptor signaling pathway via JAK-STAT
GO_0070670Biological processresponse to interleukin-4
GO_0045221Biological processnegative regulation of FasL production
GO_0070672Biological processresponse to interleukin-15
GO_0045626Biological processnegative regulation of T-helper 1 cell differentiation
GO_0006468Biological processprotein phosphorylation
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0030183Biological processB cell differentiation
GO_0070244Biological processnegative regulation of thymocyte apoptotic process
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0031234Cellular componentextrinsic component of cytoplasmic side of plasma membrane
GO_0019897Cellular componentextrinsic component of plasma membrane
GO_0005829Cellular componentcytosol
GO_0005768Cellular componentendosome
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0019903Molecular functionprotein phosphatase binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0005131Molecular functiongrowth hormone receptor binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameJAK3
Protein nameJanus kinase 3
Tyrosine-protein kinase (EC 2.7.10.2)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Synonyms
DescriptionFUNCTION: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. .

AccessionsENST00000526008.6
ENST00000458235.7 [P52333-1]
P52333
A0A0S2Z4R7
ENST00000534444.1 [P52333-2]
A0A0S2Z485
ENST00000527670.5 [P52333-1]