IL2RG | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	40 studies	57% ± 20%	Explore
CD8-positive, alpha-beta T cell	33 studies	54% ± 20%	Explore
T cell	32 studies	46% ± 18%	Explore
B cell	31 studies	39% ± 16%	Explore
CD4-positive, alpha-beta T cell	30 studies	52% ± 20%	Explore
regulatory T cell	24 studies	55% ± 22%	Explore
mature NK T cell	19 studies	54% ± 19%	Explore
naive B cell	17 studies	41% ± 14%	Explore
gamma-delta T cell	17 studies	49% ± 21%	Explore
conventional dendritic cell	16 studies	36% ± 20%	Explore
memory B cell	16 studies	38% ± 13%	Explore
plasmacytoid dendritic cell	16 studies	42% ± 13%	Explore
plasma cell	15 studies	46% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	49% ± 23%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	57% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	46% ± 14%	Explore
dendritic cell	13 studies	44% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	52% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	51% ± 23%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	57% ± 15%	Explore
mucosal invariant T cell	12 studies	54% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	52% ± 20%	Explore
T follicular helper cell	9 studies	40% ± 16%	Explore
plasmablast	8 studies	42% ± 20%	Explore
non-classical monocyte	8 studies	24% ± 7%	Explore
innate lymphoid cell	8 studies	47% ± 18%	Explore
CD4-positive helper T cell	6 studies	37% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	63% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	57% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	37% ± 17%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	66% ± 25%	Explore
leukocyte	5 studies	35% ± 13%	Explore
IgA plasma cell	5 studies	26% ± 10%	Explore
myeloid cell	5 studies	26% ± 9%	Explore
macrophage	5 studies	36% ± 22%	Explore
neutrophil	4 studies	21% ± 4%	Explore
classical monocyte	4 studies	21% ± 5%	Explore
exhausted T cell	4 studies	85% ± 7%	Explore
hematopoietic precursor cell	4 studies	31% ± 20%	Explore
monocyte	4 studies	31% ± 8%	Explore
group 3 innate lymphoid cell	4 studies	65% ± 19%	Explore
T-helper 17 cell	4 studies	63% ± 15%	Explore
T-helper 1 cell	4 studies	53% ± 16%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	54% ± 23%	Explore
IgG plasma cell	3 studies	25% ± 13%	Explore
thymocyte	3 studies	34% ± 21%	Explore
pro-B cell	3 studies	23% ± 5%	Explore
intraepithelial lymphocyte	3 studies	60% ± 19%	Explore
immature B cell	3 studies	30% ± 9%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	52% ± 11%	Explore
double negative thymocyte	3 studies	65% ± 21%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	42% ± 12%	Explore
lung	7 studies	26% ± 5%	Explore
intestine	3 studies	26% ± 7%	Explore
lymph node	3 studies	35% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	2270.70	578 / 578	88%	17.53	1017 / 1155
stomach	72%	494.52	259 / 359	95%	39.89	272 / 286
intestine	60%	1806.79	582 / 966	98%	35.62	514 / 527
breast	83%	495.17	380 / 459	68%	10.43	761 / 1118
bladder	62%	408.86	13 / 21	64%	15.16	325 / 504
esophagus	40%	265.06	582 / 1445	78%	19.25	142 / 183
thymus	61%	485.36	400 / 653	54%	22.17	326 / 605
kidney	45%	343.54	40 / 89	66%	8.49	593 / 901
liver	62%	253.27	140 / 226	47%	8.13	192 / 406
skin	42%	176.34	768 / 1809	63%	13.51	297 / 472
uterus	28%	99.76	48 / 170	72%	16.57	331 / 459
prostate	61%	339.98	150 / 245	39%	3.35	196 / 502
lymph node	0%	0	0 / 0	100%	139.77	29 / 29
peripheral blood	100%	23430.28	929 / 929	0%	0	0 / 0
spleen	100%	8657.76	241 / 241	0%	0	0 / 0
pancreas	4%	16.14	12 / 328	90%	31.19	161 / 178
adipose	93%	669.19	1122 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	38.27	41 / 45
ovary	8%	33.95	15 / 180	60%	6.86	260 / 430
blood vessel	30%	184.76	396 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	18%	1.85	14 / 80
adrenal gland	10%	35.95	27 / 258	6%	0.50	14 / 230
heart	13%	52.52	109 / 861	0%	0	0 / 0
brain	6%	25.48	164 / 2642	5%	0.55	32 / 705
muscle	1%	3.50	9 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0038110	Biological process	interleukin-2-mediated signaling pathway
GO_0038113	Biological process	interleukin-9-mediated signaling pathway
GO_0050766	Biological process	positive regulation of phagocytosis
GO_0035723	Biological process	interleukin-15-mediated signaling pathway
GO_0007165	Biological process	signal transduction
GO_0010628	Biological process	positive regulation of gene expression
GO_0032831	Biological process	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO_0002335	Biological process	mature B cell differentiation
GO_0038111	Biological process	interleukin-7-mediated signaling pathway
GO_0045579	Biological process	positive regulation of B cell differentiation
GO_0019725	Biological process	cellular homeostasis
GO_0035771	Biological process	interleukin-4-mediated signaling pathway
GO_0033077	Biological process	T cell differentiation in thymus
GO_0006955	Biological process	immune response
GO_0002361	Biological process	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO_0033089	Biological process	positive regulation of T cell differentiation in thymus
GO_0010467	Biological process	gene expression
GO_0009897	Cellular component	external side of plasma membrane
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005654	Cellular component	nucleoplasm
GO_0009986	Cellular component	cell surface
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005768	Cellular component	endosome
GO_0015026	Molecular function	coreceptor activity
GO_0004913	Molecular function	interleukin-4 receptor activity
GO_0019955	Molecular function	cytokine binding
GO_0004917	Molecular function	interleukin-7 receptor activity
GO_0019976	Molecular function	interleukin-2 binding
GO_0042010	Molecular function	interleukin-15 receptor activity
GO_0004896	Molecular function	cytokine receptor activity
GO_0004911	Molecular function	interleukin-2 receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	IL2RG
Protein name	IL2RG nirs variant 4 IL2RG nirs variant 5 Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132) IL2RG nirs variant 1 Nonfunctional common cytokine receptor gamma chain IL2RG nirs variant 3 Interleukin 2 receptor subunit gamma
Synonyms
Description	FUNCTION: Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 . .
Accessions	Q5FC10 Q5FC13 ENST00000473378.1 P31785 D6R964 A0A3G1CD75 D6RDW9 ENST00000464642.5 Q5FC09 ENST00000482750.6 H0Y8J6 Q5FC11 ENST00000374202.7 [P31785-1]

IL2RG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review