IKBKE report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IKBKE at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IKBKE at tissue level.

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0060340Biological processpositive regulation of type I interferon-mediated signaling pathway
GO_0097400Biological processinterleukin-17-mediated signaling pathway
GO_0051607Biological processdefense response to virus
GO_0048255Biological processmRNA stabilization
GO_0032481Biological processpositive regulation of type I interferon production
GO_0006955Biological processimmune response
GO_0098586Biological processcellular response to virus
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0043254Biological processregulation of protein-containing complex assembly
GO_0010467Biological processgene expression
GO_0010884Biological processpositive regulation of lipid storage
GO_0035456Biological processresponse to interferon-beta
GO_0031966Cellular componentmitochondrial membrane
GO_0005654Cellular componentnucleoplasm
GO_1902554Cellular componentserine/threonine protein kinase complex
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008384Molecular functionIkappaB kinase activity
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_0019903Molecular functionprotein phosphatase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0036435Molecular functionK48-linked polyubiquitin modification-dependent protein binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIKBKE
Protein nameInhibitor of nuclear factor kappa B kinase subunit epsilon
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
SynonymsIKKI
IKKE
KIAA0151
DescriptionFUNCTION: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. .

AccessionsENST00000584998.5 [Q14164-2]
ENST00000578328.6
A0A075B7D5
ENST00000581977.7 [Q14164-1]
Q14164
A0A075B7C7
ENST00000605726.1
ENST00000579827.6
A0A075B7B4