IRAK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002755Biological processMyD88-dependent toll-like receptor signaling pathway
GO_0031663Biological processlipopolysaccharide-mediated signaling pathway
GO_0002224Biological processtoll-like receptor signaling pathway
GO_0007254Biological processJNK cascade
GO_0034605Biological processcellular response to heat
GO_0045087Biological processinnate immune response
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0001959Biological processregulation of cytokine-mediated signaling pathway
GO_0071456Biological processcellular response to hypoxia
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0038172Biological processinterleukin-33-mediated signaling pathway
GO_0032481Biological processpositive regulation of type I interferon production
GO_0070555Biological processresponse to interleukin-1
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0071222Biological processcellular response to lipopolysaccharide
GO_1904996Biological processpositive regulation of leukocyte adhesion to vascular endothelial cell
GO_0034134Biological processtoll-like receptor 2 signaling pathway
GO_0008063Biological processToll signaling pathway
GO_0046777Biological processprotein autophosphorylation
GO_0032496Biological processresponse to lipopolysaccharide
GO_0034162Biological processtoll-like receptor 9 signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0031072Molecular functionheat shock protein binding
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIRAK1
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)
Alternative protein IRAK1
Interleukin 1 receptor associated kinase 1
SynonymsIRAK
DescriptionFUNCTION: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. .

AccessionsENST00000444230.5
P51617
H7C2I6
H7C3G8
ENST00000369974.6 [P51617-4]
ENST00000455690.5
ENST00000429936.6
ENST00000437278.5
ENST00000443220.1
F8WAB6
ENST00000369973.7
D3YTB5
L8E7M9
H7C224
ENST00000369980.8 [P51617-1]
H7C3C1
ENST00000444254.1
H7C1F0
ENST00000393687.6 [P51617-2]