TRIM65 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRIM65 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM65 at tissue level.

III. Associated gene sets

GO_0032461Biological processpositive regulation of protein oligomerization
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0050728Biological processnegative regulation of inflammatory response
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0010508Biological processpositive regulation of autophagy
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0140374Biological processantiviral innate immune response
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTRIM65
Protein nameAlternative protein TRIM65
Tripartite motif containing 65
TRIM65 protein
E3 ubiquitin-protein ligase TRIM65 (EC 2.3.2.27) (Tripartite motif-containing protein 65)
Synonyms
DescriptionFUNCTION: E3 ubiquitin ligase that plays a role in several processes including innate immnity, autophagy or inflammation . Negatively regulates miRNAs by modulating the ubiquitination and stability of TNRC6A, a protein involved in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs . This ubiquitination results in the suppressed expression of miR-138-5p leading to increased autophagy . Upon enteroviral infection, promotes 'Lys-63'-mediated ubiquitination activation of IFIH1/MDA5 leading to innate signaling cascade . Mechanistically, selectively recognizes MDA5 filaments that occur on dsRNAs . Plays also a role in limitation of inflammation through different mechanisms. First, promotes 'Lys-48'-mediated ubiquitination of VCAM1 leading to its degradation and limitation of LPS-induced lung inflammation . In addition, negatively regulates inflammasome activation by promoting 'lys48'-linked ubiquitination of NLRP3 which is critical for the inhibition of NLRP3 inflammasome activation in resting macrophages . .

AccessionsENST00000591668.5
ENST00000543309.5
H0YG27
K7EM44
L8E9Q5
ENST00000269383.8
ENST00000592642.1
H0YGS7
Q96DX1
ENST00000540128.1
K7EJ59
Q6PJ69