IFNB1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IFNB1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IFNB1 at tissue level.

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0140123Biological processnegative regulation of Lewy body formation
GO_0033141Biological processpositive regulation of peptidyl-serine phosphorylation of STAT protein
GO_0045071Biological processnegative regulation of viral genome replication
GO_0045581Biological processnegative regulation of T cell differentiation
GO_0045087Biological processinnate immune response
GO_0043330Biological processresponse to exogenous dsRNA
GO_0009615Biological processresponse to virus
GO_0051607Biological processdefense response to virus
GO_0030101Biological processnatural killer cell activation
GO_0035458Biological processcellular response to interferon-beta
GO_0045089Biological processpositive regulation of innate immune response
GO_0006959Biological processhumoral immune response
GO_0045343Biological processregulation of MHC class I biosynthetic process
GO_2000552Biological processnegative regulation of T-helper 2 cell cytokine production
GO_0002250Biological processadaptive immune response
GO_0098586Biological processcellular response to virus
GO_0070050Biological processneuron cellular homeostasis
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0002312Biological processB cell activation involved in immune response
GO_0010508Biological processpositive regulation of autophagy
GO_0042100Biological processB cell proliferation
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0071360Biological processcellular response to exogenous dsRNA
GO_0002323Biological processnatural killer cell activation involved in immune response
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0030183Biological processB cell differentiation
GO_0002286Biological processT cell activation involved in immune response
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005126Molecular functioncytokine receptor binding
GO_0008811Molecular functionchloramphenicol O-acetyltransferase activity
GO_0005132Molecular functiontype I interferon receptor binding
GO_0005125Molecular functioncytokine activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIFNB1
Protein nameInterferon beta
Interferon beta (IFN-beta) (Fibroblast interferon)
SynonymsIFNB
IFB
DescriptionFUNCTION: Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli . Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins . Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (By similarity). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (By similarity). IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity). .

AccessionsP01574
ENST00000380232.4
B5BUQ5