SP100 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0046826Biological processnegative regulation of protein export from nucleus
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0060333Biological processtype II interferon-mediated signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0034341Biological processresponse to type II interferon
GO_0045765Biological processregulation of angiogenesis
GO_1902044Biological processregulation of Fas signaling pathway
GO_0045185Biological processmaintenance of protein location
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0000723Biological processtelomere maintenance
GO_0043392Biological processnegative regulation of DNA binding
GO_0010596Biological processnegative regulation of endothelial cell migration
GO_1902041Biological processregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0034340Biological processresponse to type I interferon
GO_0030330Biological processDNA damage response, signal transduction by p53 class mediator
GO_0030870Cellular componentMre11 complex
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0019904Molecular functionprotein domain specific binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0070087Molecular functionchromo shadow domain binding
GO_0019900Molecular functionkinase binding
GO_0042802Molecular functionidentical protein binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSP100
Protein nameUncharacterized protein SP100
Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)
SP100 nuclear antigen
SP100-HMG nuclear autoantigen
Synonyms
DescriptionFUNCTION: Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. .

AccessionsH0Y4R8
C9JBL0
ENST00000432979.5
ENST00000409112.5 [P23497-3]
Q53TD0
ENST00000427101.6 [P23497-6]
ENST00000409897.5 [P23497-7]
H7C1G8
ENST00000340126.9 [P23497-4]
ENST00000431952.1
Q4ZG64
ENST00000264052.9 [P23497-1]
H7C4B4
P23497
E9PHV6
ENST00000452345.1
ENST00000409824.5
ENST00000409341.5 [P23497-2]
ENST00000413284.5
Q9P0W1