HDAC4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0016925Biological processprotein sumoylation
GO_0006954Biological processinflammatory response
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0014898Biological processcardiac muscle hypertrophy in response to stress
GO_0014894Biological processresponse to denervation involved in regulation of muscle adaptation
GO_0006476Biological processprotein deacetylation
GO_0010944Biological processnegative regulation of transcription by competitive promoter binding
GO_0070555Biological processresponse to interleukin-1
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0006338Biological processchromatin remodeling
GO_0043393Biological processregulation of protein binding
GO_0045820Biological processnegative regulation of glycolytic process
GO_0010832Biological processnegative regulation of myotube differentiation
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0033235Biological processpositive regulation of protein sumoylation
GO_0034983Biological processpeptidyl-lysine deacetylation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0042113Biological processB cell activation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0007399Biological processnervous system development
GO_0030183Biological processB cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0000118Cellular componenthistone deacetylase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0033558Molecular functionprotein lysine deacetylase activity
GO_0019789Molecular functionSUMO transferase activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0042393Molecular functionhistone binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0004407Molecular functionhistone deacetylase activity
GO_0042802Molecular functionidentical protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0030955Molecular functionpotassium ion binding
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameHDAC4
Protein nameHistone deacetylase 4 (HD4) (EC 3.5.1.98)
Histone deacetylase (EC 3.5.1.98)
histone deacetylase (EC 3.5.1.98)
Histone deacetylase 4
SynonymsKIAA0288
DescriptionFUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. .

FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 . .

AccessionsENST00000543185.6
ENST00000446876.1
ENST00000454542.5
P56524
A0A7I2SVS4
ENST00000445704.1
C9J0X4
H7C397
ENST00000430200.1
C9J481
H7BZT3
ENST00000345617.7 [P56524-1]