IFNAR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009615Biological processresponse to virus
GO_0051607Biological processdefense response to virus
GO_0035455Biological processresponse to interferon-alpha
GO_0035458Biological processcellular response to interferon-beta
GO_0098586Biological processcellular response to virus
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0046425Biological processregulation of receptor signaling pathway via JAK-STAT
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0035456Biological processresponse to interferon-beta
GO_0140865Biological processinterleukin-22-mediated signaling pathway
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0004905Molecular functiontype I interferon receptor activity
GO_0019955Molecular functioncytokine binding
GO_0019901Molecular functionprotein kinase binding
GO_0042018Molecular functioninterleukin-22 receptor activity
GO_0008269Molecular functionJAK pathway signal transduction adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIFNAR2
Protein nameInterferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2)
Interferon (Alpha, beta and omega) receptor 2
Interferon alpha and beta receptor subunit 2
SynonymsIFNABR
IFNARB
DescriptionFUNCTION: Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) . Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response . Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another . The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT) . STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes . .; FUNCTION: [Isoform 3]: Potent inhibitor of type I IFN receptor activity. .

AccessionsENST00000342101.7 [P48551-3]
C9JM33
ENST00000443073.5
ENST00000683941.1 [P48551-1]
S6FRS2
F8WDE1
A0A804HLE8
H7C176
C9JCU0
ENST00000382238.6
ENST00000342136.9 [P48551-1]
ENST00000404220.7 [P48551-2]
ENST00000382264.7 [P48551-2]
ENST00000447980.1
ENST00000682044.1
ENST00000417007.1
ENST00000413881.5
C9K067
P48551
Q9BUA0