IRF7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002376Biological processimmune system process
GO_0019043Biological processestablishment of viral latency
GO_0032728Biological processpositive regulation of interferon-beta production
GO_2000110Biological processnegative regulation of macrophage apoptotic process
GO_0060340Biological processpositive regulation of type I interferon-mediated signaling pathway
GO_0034127Biological processregulation of MyD88-independent toll-like receptor signaling pathway
GO_0045087Biological processinnate immune response
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0009615Biological processresponse to virus
GO_0051607Biological processdefense response to virus
GO_0006974Biological processDNA damage response
GO_0034124Biological processregulation of MyD88-dependent toll-like receptor signaling pathway
GO_0032481Biological processpositive regulation of type I interferon production
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032479Biological processregulation of type I interferon production
GO_0050776Biological processregulation of immune response
GO_0002819Biological processregulation of adaptive immune response
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0016064Biological processimmunoglobulin mediated immune response
GO_0045655Biological processregulation of monocyte differentiation
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0039530Biological processMDA-5 signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIRF7
Protein nameInterferon regulatory factor 7, isoform CRA_c (cDNA FLJ61529, highly similar to Interferon regulatory factor 7)
Interferon regulatory factor 7 (IRF-7)
Interferon regulatory factor 7
SynonymshCG_18132
DescriptionFUNCTION: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses . Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters . Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) . .

AccessionsENST00000330243.9 [Q92985-4]
A0A3B3ISC0
ENST00000612534.4 [Q92985-4]
ENST00000647801.1
ENST00000621391.4 [Q92985-1]
A0A3B3ISS4
ENST00000617397.1
A0A3B3ITQ5
ENST00000469048.6 [Q92985-3]
E9PSE3
ENST00000633274.1 [Q92985-3]
ENST00000532326.5
ENST00000533182.5 [Q92985-3]
ENST00000634105.1 [Q92985-3]
ENST00000649187.1
ENST00000632194.1
ENST00000348655.11 [Q92985-2]
M9RSF4
ENST00000631879.1
ENST00000633943.1 [Q92985-2]
B4E1B1
ENST00000397570.5
E9PIA7
ENST00000528413.6
ENST00000397566.5 [Q92985-4]
ENST00000632827.1 [Q92985-4]
ENST00000525445.6 [Q92985-1]
Q92985