OAS2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OAS2 at tissue level.

III. Associated gene sets

GO_0006139Biological processnucleobase-containing compound metabolic process
GO_0045071Biological processnegative regulation of viral genome replication
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0009615Biological processresponse to virus
GO_0051607Biological processdefense response to virus
GO_0006401Biological processRNA catabolic process
GO_0060700Biological processregulation of ribonuclease activity
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0042742Biological processdefense response to bacterium
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0070106Biological processinterleukin-27-mediated signaling pathway
GO_1903487Biological processregulation of lactation
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0001730Molecular function2'-5'-oligoadenylate synthetase activity
GO_0005515Molecular functionprotein binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameOAS2
Protein name2'-5'-oligoadenylate synthetase 2, 69/71kDa
2'-5' oligoadenylate synthase (EC 2.7.7.84)
2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS)
2'-5'-oligoadenylate synthetase 2
Synonyms
DescriptionFUNCTION: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response . Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation . Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication . Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL . In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation . May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity). .

AccessionsENST00000552756.6
Q7Z6D0
A0A087X0V5
ENST00000342315.8 [P29728-1]
ENST00000680514.1
F8VPI5
A0A7P0TAE6
ENST00000680138.1
A0A7P0TAV1
ENST00000680122.1
A0A7P0T9B5
ENST00000680685.1
ENST00000392583.7 [P29728-2]
A0A7P0T8H9
ENST00000449768.2 [P29728-3]
ENST00000679877.1
ENST00000551603.2
P29728
F8W1C5
ENST00000620097.2