IFIH1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IFIH1 at tissue level.

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_0034344Biological processregulation of type III interferon production
GO_0045071Biological processnegative regulation of viral genome replication
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0045087Biological processinnate immune response
GO_0009615Biological processresponse to virus
GO_0051607Biological processdefense response to virus
GO_0060760Biological processpositive regulation of response to cytokine stimulus
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0009597Biological processdetection of virus
GO_0098586Biological processcellular response to virus
GO_0051259Biological processprotein complex oligomerization
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0071360Biological processcellular response to exogenous dsRNA
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0039530Biological processMDA-5 signaling pathway
GO_0140374Biological processantiviral innate immune response
GO_0005739Cellular componentmitochondrion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0038187Molecular functionpattern recognition receptor activity
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0003724Molecular functionRNA helicase activity
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0042802Molecular functionidentical protein binding
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameIFIH1
Protein nameInterferon induced with helicase C domain 1
Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116)
RNA helicase (EC 3.6.4.13)
SynonymsMDA5
RH116
DescriptionFUNCTION: Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines . Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length) . Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and rhinovirus . Detects coronavirus SARS-CoV-2 . Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. .

AccessionsA0A3B3IRK8
ENST00000421365.2 [Q9BYX4-2]
ENST00000649979.2 [Q9BYX4-1]
Q9BYX4
A0A7P0Z4A9
ENST00000697291.1
ENST00000648433.1
ENST00000679938.1
A0A8V8TKX2