TBK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0006954Biological processinflammatory response
GO_0060340Biological processpositive regulation of type I interferon-mediated signaling pathway
GO_0010629Biological processnegative regulation of gene expression
GO_0045087Biological processinnate immune response
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0009615Biological processresponse to virus
GO_0051607Biological processdefense response to virus
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0032481Biological processpositive regulation of type I interferon production
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0032479Biological processregulation of type I interferon production
GO_1904417Biological processpositive regulation of xenophagy
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0140896Biological processcGAS/STING signaling pathway
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0016239Biological processpositive regulation of macroautophagy
GO_0010508Biological processpositive regulation of autophagy
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0002218Biological processactivation of innate immune response
GO_0044565Biological processdendritic cell proliferation
GO_0006468Biological processprotein phosphorylation
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0140374Biological processantiviral innate immune response
GO_0005654Cellular componentnucleoplasm
GO_1902554Cellular componentserine/threonine protein kinase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0106310Molecular functionprotein serine kinase activity
GO_0003676Molecular functionnucleic acid binding
GO_0019903Molecular functionprotein phosphatase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0051219Molecular functionphosphoprotein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTBK1
Protein nameSerine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
TANK binding kinase 1
SynonymsNAK
DescriptionFUNCTION: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents . Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X . This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB . In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli . Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 . Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons . Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes . Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus . Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy . Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation . Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes . Phosphorylates and activates AKT1 . Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C . Phosphorylates Borna disease virus (BDV) P protein . Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system . Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR . .

AccessionsF5H206
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Q9UHD2
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F5GZI4