MYD88 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007254Biological processJNK cascade
GO_0032722Biological processpositive regulation of chemokine production
GO_0071260Biological processcellular response to mechanical stimulus
GO_0032747Biological processpositive regulation of interleukin-23 production
GO_0038172Biological processinterleukin-33-mediated signaling pathway
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0006909Biological processphagocytosis
GO_0008063Biological processToll signaling pathway
GO_0032740Biological processpositive regulation of interleukin-17 production
GO_0007166Biological processcell surface receptor signaling pathway
GO_0043200Biological processresponse to amino acid
GO_1902622Biological processregulation of neutrophil migration
GO_0045087Biological processinnate immune response
GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_0050727Biological processregulation of inflammatory response
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0032494Biological processresponse to peptidoglycan
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0050671Biological processpositive regulation of lymphocyte proliferation
GO_0016064Biological processimmunoglobulin mediated immune response
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0010467Biological processgene expression
GO_0043588Biological processskin development
GO_0034158Biological processtoll-like receptor 8 signaling pathway
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0002755Biological processMyD88-dependent toll-like receptor signaling pathway
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0032481Biological processpositive regulation of type I interferon production
GO_2000338Biological processregulation of chemokine (C-X-C motif) ligand 1 production
GO_0045471Biological processresponse to ethanol
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0060907Biological processpositive regulation of macrophage cytokine production
GO_0090557Biological processestablishment of endothelial intestinal barrier
GO_0070944Biological processneutrophil-mediated killing of bacterium
GO_0140052Biological processcellular response to oxidised low-density lipoprotein particle stimulus
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0002283Biological processneutrophil activation involved in immune response
GO_0031663Biological processlipopolysaccharide-mediated signaling pathway
GO_0014075Biological processresponse to amine
GO_0002269Biological processleukocyte activation involved in inflammatory response
GO_0042832Biological processdefense response to protozoan
GO_0046330Biological processpositive regulation of JNK cascade
GO_0002238Biological processresponse to molecule of fungal origin
GO_0051607Biological processdefense response to virus
GO_2000341Biological processregulation of chemokine (C-X-C motif) ligand 2 production
GO_0014070Biological processresponse to organic cyclic compound
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0070555Biological processresponse to interleukin-1
GO_0006338Biological processchromatin remodeling
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_0014004Biological processmicroglia differentiation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0042742Biological processdefense response to bacterium
GO_0070935Biological process3'-UTR-mediated mRNA stabilization
GO_0006915Biological processapoptotic process
GO_0009682Biological processinduced systemic resistance
GO_0031234Cellular componentextrinsic component of cytoplasmic side of plasma membrane
GO_0009986Cellular componentcell surface
GO_0010008Cellular componentendosome membrane
GO_0005634Cellular componentnucleus
GO_0019897Cellular componentextrinsic component of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005737Cellular componentcytoplasm
GO_0005829Cellular componentcytosol
GO_0005149Molecular functioninterleukin-1 receptor binding
GO_0042802Molecular functionidentical protein binding
GO_0005121Molecular functionToll binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0035325Molecular functionToll-like receptor binding
GO_0070976Molecular functionTIR domain binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0140674Molecular functionATP-dependent histone chaperone activity
GO_0005515Molecular functionprotein binding
GO_0005123Molecular functiondeath receptor binding

IV. Literature review

[source]
Gene nameMYD88
Protein nameMyeloid differentiation primary response 88
Myeloid differentiation primary response protein MyD88
Mutant myeloid differentiation primary response 88
Synonyms
DescriptionFUNCTION: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response . Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Increases IL-8 transcription . Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation . MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). .

FUNCTION: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. .

FUNCTION: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. .

AccessionsENST00000417037.8 [Q99836-2]
A0A8V8TP38
ENST00000651800.2 [Q99836-3]
A0A192GQD4
A0A192GP51
A0A3F2YP85
ENST00000650905.2 [Q99836-1]
ENST00000699086.1
ENST00000417037
ENST00000650112.2 [Q99836-4]
A0A3B3ITY3
ENST00000650112
A0A494C0J8
A0A193CK37
ENST00000652213.1
ENST00000421516.3 [Q99836-6]
A0A192GQL6
ENST00000651800
A0A0A0MSI9
Q99836