MAVS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071660Biological processpositive regulation of IP-10 production
GO_0045071Biological processnegative regulation of viral genome replication
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0070585Biological processprotein localization to mitochondrion
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0060340Biological processpositive regulation of type I interferon-mediated signaling pathway
GO_0045087Biological processinnate immune response
GO_0002735Biological processpositive regulation of myeloid dendritic cell cytokine production
GO_0007165Biological processsignal transduction
GO_0051607Biological processdefense response to virus
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0060760Biological processpositive regulation of response to cytokine stimulus
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0032481Biological processpositive regulation of type I interferon production
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_0071651Biological processpositive regulation of chemokine (C-C motif) ligand 5 production
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0042742Biological processdefense response to bacterium
GO_0002218Biological processactivation of innate immune response
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0071360Biological processcellular response to exogenous dsRNA
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0140374Biological processantiviral innate immune response
GO_1900063Biological processregulation of peroxisome organization
GO_0005778Cellular componentperoxisomal membrane
GO_0000151Cellular componentubiquitin ligase complex
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0005741Cellular componentmitochondrial outer membrane
GO_0050700Molecular functionCARD domain binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0039552Molecular functionRIG-I binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAVS
Protein nameMitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Alternative protein MAVS
SynonymsIPS1
VISA
KIAA1271
DescriptionFUNCTION: Adapter required for innate immune defense against viruses . Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) . Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state . Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response . May activate the same pathways following detection of extracellular dsRNA by TLR3 . May protect cells from apoptosis . Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria . .

AccessionsQ7Z434
L8E900
ENST00000428216.4 [Q7Z434-1]
ENST00000416600.6 [Q7Z434-4]