IFNAR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009615Biological processresponse to virus
GO_0098586Biological processcellular response to virus
GO_0060337Biological processtype I interferon-mediated signaling pathway
GO_0035457Biological processcellular response to interferon-alpha
GO_0046425Biological processregulation of receptor signaling pathway via JAK-STAT
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_1901857Biological processpositive regulation of cellular respiration
GO_0032496Biological processresponse to lipopolysaccharide
GO_0035458Biological processcellular response to interferon-beta
GO_0005764Cellular componentlysosome
GO_0005886Cellular componentplasma membrane
GO_0005770Cellular componentlate endosome
GO_0004905Molecular functiontype I interferon receptor activity
GO_0019955Molecular functioncytokine binding
GO_0019962Molecular functiontype I interferon binding
GO_0008269Molecular functionJAK pathway signal transduction adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIFNAR1
Protein nameInterferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Type I interferon receptor 1)
Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)
Interferon alpha and beta receptor subunit 1
SynonymsIFNAR
DescriptionFUNCTION: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) . Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response . Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another . The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors . STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes . Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). .

FUNCTION: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. .

AccessionsA0A994J3P7
ENST00000703561.1
ENST00000703564.1
ENST00000703779.1
A0A494BZU5
ENST00000652513.2
ENST00000703516.1
ENST00000652654.3
C9J114
A0A494C0P2
A0A494C0K3
ENST00000700080.1 [P17181-4]
ENST00000703515.1 [P17181-1]
A0A8V8TQK8
A0A8V8TQJ9
P17181
ENST00000703563.1
ENST00000651609.2
ENST00000703565.1
A0A994J6F9
ENST00000652450.2 [P17181-4]
ENST00000700046.1
A0A994J6F6
ENST00000703556.1 [P17181-1]
ENST00000703514.1
ENST00000703562.1
ENST00000703557.1
A0A994J4B0
ENST00000652601.1
A0A994J6V0
ENST00000442071.3
ENST00000270139.8 [P17181-1]
A0A494C0E2
A0A994J479
ENST00000700084.1