Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 25 studies | 25% ± 11% | |
macrophage | 23 studies | 25% ± 8% | |
non-classical monocyte | 15 studies | 24% ± 8% | |
B cell | 14 studies | 20% ± 3% | |
classical monocyte | 14 studies | 25% ± 7% | |
naive B cell | 12 studies | 23% ± 3% | |
plasmacytoid dendritic cell | 12 studies | 28% ± 9% | |
fibroblast | 11 studies | 23% ± 10% | |
plasma cell | 11 studies | 29% ± 11% | |
monocyte | 8 studies | 21% ± 4% | |
endothelial cell of artery | 8 studies | 20% ± 3% | |
memory B cell | 8 studies | 21% ± 3% | |
capillary endothelial cell | 7 studies | 19% ± 4% | |
epithelial cell | 7 studies | 30% ± 14% | |
ciliated cell | 7 studies | 24% ± 8% | |
endothelial cell of lymphatic vessel | 6 studies | 21% ± 4% | |
basal cell | 6 studies | 23% ± 7% | |
endothelial cell of vascular tree | 6 studies | 18% ± 2% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 5 studies | 18% ± 2% | |
microglial cell | 5 studies | 25% ± 7% | |
myeloid cell | 5 studies | 29% ± 12% | |
dendritic cell | 5 studies | 26% ± 12% | |
oligodendrocyte precursor cell | 5 studies | 27% ± 11% | |
type I pneumocyte | 4 studies | 23% ± 3% | |
plasmablast | 4 studies | 48% ± 20% | |
club cell | 4 studies | 22% ± 6% | |
secretory cell | 4 studies | 23% ± 4% | |
CD4-positive, alpha-beta T cell | 4 studies | 17% ± 3% | |
conventional dendritic cell | 4 studies | 32% ± 8% | |
pericyte | 4 studies | 22% ± 5% | |
GABAergic neuron | 4 studies | 37% ± 11% | |
glutamatergic neuron | 4 studies | 43% ± 17% | |
abnormal cell | 4 studies | 23% ± 4% | |
interneuron | 4 studies | 32% ± 18% | |
oligodendrocyte | 4 studies | 27% ± 3% | |
astrocyte | 4 studies | 23% ± 6% | |
neutrophil | 3 studies | 18% ± 4% | |
respiratory goblet cell | 3 studies | 27% ± 13% | |
squamous epithelial cell | 3 studies | 36% ± 24% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 3 studies | 17% ± 1% | |
glomerular endothelial cell | 3 studies | 25% ± 3% | |
IgG plasma cell | 3 studies | 16% ± 1% | |
precursor B cell | 3 studies | 26% ± 2% | |
immature B cell | 3 studies | 30% ± 2% | |
natural killer cell | 3 studies | 16% ± 0% | |
retina horizontal cell | 3 studies | 19% ± 3% | |
retinal cone cell | 3 studies | 26% ± 5% | |
mononuclear phagocyte | 3 studies | 22% ± 6% | |
lymphocyte | 3 studies | 18% ± 3% | |
intermediate monocyte | 3 studies | 28% ± 13% | |
leukocyte | 3 studies | 17% ± 2% | |
neuron | 3 studies | 25% ± 9% | |
regulatory T cell | 3 studies | 20% ± 2% | |
IgA plasma cell | 3 studies | 17% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2666.94 | 1445 / 1445 | 100% | 34.22 | 183 / 183 |
kidney | 100% | 2965.20 | 89 / 89 | 100% | 51.25 | 901 / 901 |
liver | 100% | 4419.72 | 226 / 226 | 100% | 34.21 | 406 / 406 |
prostate | 100% | 3160.99 | 245 / 245 | 100% | 59.58 | 502 / 502 |
thymus | 100% | 3730.66 | 653 / 653 | 100% | 50.53 | 605 / 605 |
brain | 100% | 2635.16 | 2640 / 2642 | 100% | 49.41 | 705 / 705 |
breast | 100% | 4090.91 | 459 / 459 | 100% | 50.50 | 1117 / 1118 |
lung | 100% | 3985.94 | 577 / 578 | 100% | 40.73 | 1155 / 1155 |
bladder | 100% | 3361.90 | 21 / 21 | 100% | 35.81 | 503 / 504 |
uterus | 100% | 2752.01 | 170 / 170 | 100% | 35.96 | 458 / 459 |
pancreas | 100% | 2386.55 | 327 / 328 | 100% | 38.60 | 178 / 178 |
stomach | 100% | 2681.53 | 359 / 359 | 100% | 33.27 | 285 / 286 |
intestine | 100% | 3024.93 | 966 / 966 | 100% | 32.35 | 525 / 527 |
ovary | 100% | 2918.61 | 180 / 180 | 100% | 33.64 | 428 / 430 |
skin | 100% | 3351.01 | 1808 / 1809 | 99% | 40.76 | 466 / 472 |
adrenal gland | 100% | 3112.13 | 258 / 258 | 98% | 32.51 | 226 / 230 |
adipose | 100% | 4721.18 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 34.78 | 29 / 29 |
spleen | 100% | 4210.75 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 38.65 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 18.07 | 1 / 1 |
blood vessel | 100% | 3353.09 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 100% | 2069.25 | 858 / 861 | 0% | 0 | 0 / 0 |
muscle | 99% | 1556.78 | 797 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 5006.49 | 920 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 89% | 19.65 | 71 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0009615 | Biological process | response to virus |
GO_0098586 | Biological process | cellular response to virus |
GO_0060337 | Biological process | type I interferon-mediated signaling pathway |
GO_0035457 | Biological process | cellular response to interferon-alpha |
GO_0046425 | Biological process | regulation of receptor signaling pathway via JAK-STAT |
GO_0007259 | Biological process | cell surface receptor signaling pathway via JAK-STAT |
GO_1901857 | Biological process | positive regulation of cellular respiration |
GO_0032496 | Biological process | response to lipopolysaccharide |
GO_0035458 | Biological process | cellular response to interferon-beta |
GO_0005764 | Cellular component | lysosome |
GO_0005886 | Cellular component | plasma membrane |
GO_0005770 | Cellular component | late endosome |
GO_0004905 | Molecular function | type I interferon receptor activity |
GO_0019955 | Molecular function | cytokine binding |
GO_0019962 | Molecular function | type I interferon binding |
GO_0008269 | Molecular function | JAK pathway signal transduction adaptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | IFNAR1 |
Protein name | Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Type I interferon receptor 1) Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1) Interferon alpha and beta receptor subunit 1 |
Synonyms | IFNAR |
Description | FUNCTION: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) . Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response . Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another . The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors . STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes . Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). . FUNCTION: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. . |
Accessions | A0A994J3P7 ENST00000703561.1 ENST00000703564.1 ENST00000703779.1 A0A494BZU5 ENST00000652513.2 ENST00000703516.1 ENST00000652654.3 C9J114 A0A494C0P2 A0A494C0K3 ENST00000700080.1 [P17181-4] ENST00000703515.1 [P17181-1] A0A8V8TQK8 A0A8V8TQJ9 P17181 ENST00000703563.1 ENST00000651609.2 ENST00000703565.1 A0A994J6F9 ENST00000652450.2 [P17181-4] ENST00000700046.1 A0A994J6F6 ENST00000703556.1 [P17181-1] ENST00000703514.1 ENST00000703562.1 ENST00000703557.1 A0A994J4B0 ENST00000652601.1 A0A994J6V0 ENST00000442071.3 ENST00000270139.8 [P17181-1] A0A494C0E2 A0A994J479 ENST00000700084.1 |