KRT18 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045104Biological processintermediate filament cytoskeleton organization
GO_0097284Biological processhepatocyte apoptotic process
GO_0009653Biological processanatomical structure morphogenesis
GO_0043001Biological processGolgi to plasma membrane protein transport
GO_0098609Biological processcell-cell adhesion
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0005730Cellular componentnucleolus
GO_0005856Cellular componentcytoskeleton
GO_0034451Cellular componentcentriolar satellite
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005815Cellular componentmicrotubule organizing center
GO_0070062Cellular componentextracellular exosome
GO_0005882Cellular componentintermediate filament
GO_0016363Cellular componentnuclear matrix
GO_0005829Cellular componentcytosol
GO_0071944Cellular componentcell periphery
GO_0005912Cellular componentadherens junction
GO_0045095Cellular componentkeratin filament
GO_0005737Cellular componentcytoplasm
GO_0005198Molecular functionstructural molecule activity
GO_0097110Molecular functionscaffold protein binding
GO_0098641Molecular functioncadherin binding involved in cell-cell adhesion
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKRT18
Protein nameKRT18 protein
Keratin 18
Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)
SynonymsPIG46
CYK18
DescriptionFUNCTION: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. .

AccessionsF8VZY9
ENST00000388835.4
ENST00000550600.5
I6L965
ENST00000388837.6
P05783