PARP2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PARP2 at tissue level.

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0006281Biological processDNA repair
GO_0046697Biological processdecidualization
GO_0061051Biological processpositive regulation of cell growth involved in cardiac muscle cell development
GO_0006302Biological processdouble-strand break repair
GO_0140861Biological processDNA repair-dependent chromatin remodeling
GO_0006974Biological processDNA damage response
GO_0030592Biological processDNA ADP-ribosylation
GO_0110088Biological processhippocampal neuron apoptotic process
GO_0070212Biological processprotein poly-ADP-ribosylation
GO_0090649Biological processresponse to oxygen-glucose deprivation
GO_0006284Biological processbase-excision repair
GO_0070213Biological processprotein auto-ADP-ribosylation
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0090734Cellular componentsite of DNA damage
GO_0005634Cellular componentnucleus
GO_0016779Molecular functionnucleotidyltransferase activity
GO_0160004Molecular functionpoly-ADP-D-ribose modification-dependent protein binding
GO_0003950Molecular functionNAD+ ADP-ribosyltransferase activity
GO_0003682Molecular functionchromatin binding
GO_0140807Molecular functionNAD+-protein-glutamate ADP-ribosyltransferase activity
GO_0140805Molecular functionNAD+-protein-serine ADP-ribosyltransferase activity
GO_0140806Molecular functionNAD+- protein-aspartate ADP-ribosyltransferase activity
GO_0072572Molecular functionpoly-ADP-D-ribose binding
GO_0140294Molecular functionNAD DNA ADP-ribosyltransferase activity
GO_0031491Molecular functionnucleosome binding
GO_1990404Molecular functionNAD+-protein ADP-ribosyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene namePARP2
Protein namePoly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-)
Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-)
Poly(ADP-ribose) polymerase 2
SynonymsADPRTL2
ADPRT2
hCG_40481
DescriptionFUNCTION: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair . Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units . Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage . Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1 . Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP2 active site . PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks . HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP2 in order to limit the length of poly-ADP-ribose chains . Specifically mediates formation of branched poly-ADP-ribosylation . Branched poly-ADP-ribose chains are specifically recognized by some factors, such as APLF . In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex . .

AccessionsENST00000250416.9 [Q9UGN5-1]
ENST00000429687.8 [Q9UGN5-2]
ENST00000539930.1
ENST00000527915.5
H0YH02
E9PJ27
G3V167
ENST00000708823.1 [Q9UGN5-1]
ENST00000529465.6
Q9UGN5
ENST00000708822.1 [Q9UGN5-2]