BAX | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	33 studies	33% ± 12%	Explore
CD8-positive, alpha-beta T cell	30 studies	35% ± 16%	Explore
B cell	29 studies	28% ± 10%	Explore
CD4-positive, alpha-beta T cell	28 studies	29% ± 13%	Explore
macrophage	25 studies	35% ± 11%	Explore
classical monocyte	24 studies	33% ± 13%	Explore
T cell	23 studies	29% ± 9%	Explore
non-classical monocyte	23 studies	40% ± 16%	Explore
conventional dendritic cell	21 studies	36% ± 16%	Explore
regulatory T cell	21 studies	34% ± 15%	Explore
endothelial cell	20 studies	30% ± 10%	Explore
monocyte	18 studies	33% ± 8%	Explore
dendritic cell	17 studies	39% ± 22%	Explore
mature NK T cell	17 studies	29% ± 8%	Explore
plasmacytoid dendritic cell	17 studies	34% ± 11%	Explore
memory B cell	16 studies	26% ± 5%	Explore
naive B cell	16 studies	24% ± 7%	Explore
fibroblast	15 studies	23% ± 9%	Explore
pericyte	14 studies	21% ± 7%	Explore
gamma-delta T cell	14 studies	33% ± 14%	Explore
mast cell	13 studies	23% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	37% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	30% ± 9%	Explore
epithelial cell	11 studies	35% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	32% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	35% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	34% ± 10%	Explore
mucosal invariant T cell	10 studies	27% ± 7%	Explore
capillary endothelial cell	10 studies	21% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	24% ± 5%	Explore
myeloid cell	9 studies	36% ± 12%	Explore
endothelial cell of lymphatic vessel	8 studies	28% ± 8%	Explore
plasmablast	8 studies	38% ± 24%	Explore
abnormal cell	8 studies	25% ± 6%	Explore
endothelial cell of vascular tree	8 studies	21% ± 4%	Explore
basal cell	8 studies	28% ± 15%	Explore
alveolar macrophage	7 studies	40% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	33% ± 13%	Explore
connective tissue cell	7 studies	22% ± 5%	Explore
endothelial cell of artery	7 studies	21% ± 5%	Explore
smooth muscle cell	7 studies	23% ± 10%	Explore
ciliated cell	7 studies	32% ± 13%	Explore
T follicular helper cell	7 studies	27% ± 6%	Explore
hematopoietic precursor cell	6 studies	35% ± 17%	Explore
plasma cell	6 studies	34% ± 9%	Explore
leukocyte	6 studies	26% ± 11%	Explore
goblet cell	6 studies	25% ± 12%	Explore
vein endothelial cell	6 studies	22% ± 5%	Explore
precursor B cell	6 studies	33% ± 9%	Explore
innate lymphoid cell	6 studies	27% ± 9%	Explore
exhausted T cell	5 studies	48% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	44% ± 21%	Explore
mononuclear phagocyte	5 studies	35% ± 16%	Explore
progenitor cell	5 studies	19% ± 2%	Explore
enterocyte	5 studies	25% ± 2%	Explore
transit amplifying cell	5 studies	22% ± 3%	Explore
hematopoietic stem cell	5 studies	23% ± 6%	Explore
pro-B cell	5 studies	27% ± 4%	Explore
myofibroblast cell	4 studies	23% ± 8%	Explore
immature B cell	4 studies	28% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	45% ± 18%	Explore
neutrophil	4 studies	17% ± 1%	Explore
enteroendocrine cell	4 studies	34% ± 16%	Explore
secretory cell	4 studies	39% ± 13%	Explore
T-helper 17 cell	4 studies	33% ± 17%	Explore
glomerular endothelial cell	3 studies	18% ± 1%	Explore
epithelial cell of proximal tubule	3 studies	23% ± 3%	Explore
intestinal crypt stem cell	3 studies	24% ± 7%	Explore
neural crest cell	3 studies	18% ± 2%	Explore
lymphocyte	3 studies	40% ± 7%	Explore
megakaryocyte	3 studies	31% ± 6%	Explore
club cell	3 studies	30% ± 3%	Explore
type II pneumocyte	3 studies	31% ± 18%	Explore
microglial cell	3 studies	34% ± 10%	Explore
intraepithelial lymphocyte	3 studies	33% ± 10%	Explore
germinal center B cell	3 studies	29% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	53% ± 13%	Explore
intermediate monocyte	3 studies	49% ± 21%	Explore
neuron	3 studies	28% ± 15%	Explore
granulocyte	3 studies	23% ± 5%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	42% ± 26%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 13%	Explore
T-helper 1 cell	3 studies	44% ± 13%	Explore
erythrocyte	3 studies	33% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	28% ± 11%	Explore
peripheral blood	15 studies	33% ± 12%	Explore
intestine	9 studies	22% ± 9%	Explore
kidney	6 studies	25% ± 9%	Explore
lymph node	5 studies	32% ± 8%	Explore
placenta	4 studies	22% ± 3%	Explore
bone marrow	4 studies	25% ± 6%	Explore
liver	4 studies	35% ± 18%	Explore
uterus	3 studies	33% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	100%	2958.78	1808 / 1809	100%	111.75	472 / 472
esophagus	100%	1511.48	1444 / 1445	100%	44.86	183 / 183
uterus	100%	1607.99	170 / 170	100%	105.51	458 / 459
thymus	100%	1753.29	652 / 653	100%	96.36	604 / 605
intestine	100%	2267.04	966 / 966	100%	100.94	525 / 527
ovary	100%	1189.27	180 / 180	100%	41.38	428 / 430
prostate	100%	1813.66	245 / 245	99%	67.71	498 / 502
bladder	100%	1852.29	21 / 21	99%	109.91	499 / 504
lung	100%	2830.33	578 / 578	99%	71.11	1143 / 1155
stomach	100%	1373.25	359 / 359	99%	82.09	283 / 286
kidney	100%	1812.17	89 / 89	99%	72.72	891 / 901
breast	100%	1545.30	459 / 459	98%	59.36	1101 / 1118
liver	100%	1005.40	225 / 226	99%	65.31	401 / 406
brain	98%	854.01	2579 / 2642	100%	65.92	704 / 705
adrenal gland	100%	1799.54	258 / 258	97%	50.98	224 / 230
pancreas	97%	875.74	317 / 328	99%	89.34	177 / 178
adipose	100%	1570.85	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	104.93	80 / 80
lymph node	0%	0	0 / 0	100%	256.06	29 / 29
spleen	100%	4716.65	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	92.23	45 / 45
ureter	0%	0	0 / 0	100%	121.41	1 / 1
blood vessel	100%	1468.46	1331 / 1335	0%	0	0 / 0
peripheral blood	100%	4348.35	926 / 929	0%	0	0 / 0
heart	97%	794.95	836 / 861	0%	0	0 / 0
muscle	83%	529.64	664 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1902445	Biological process	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO_0001974	Biological process	blood vessel remodeling
GO_0048147	Biological process	negative regulation of fibroblast proliferation
GO_1902512	Biological process	positive regulation of apoptotic DNA fragmentation
GO_0009651	Biological process	response to salt stress
GO_0001541	Biological process	ovarian follicle development
GO_0010332	Biological process	response to gamma radiation
GO_0001764	Biological process	neuron migration
GO_0001777	Biological process	T cell homeostatic proliferation
GO_0031334	Biological process	positive regulation of protein-containing complex assembly
GO_0060068	Biological process	vagina development
GO_1900103	Biological process	positive regulation of endoplasmic reticulum unfolded protein response
GO_1902262	Biological process	apoptotic process involved in blood vessel morphogenesis
GO_0097192	Biological process	extrinsic apoptotic signaling pathway in absence of ligand
GO_0010917	Biological process	negative regulation of mitochondrial membrane potential
GO_2001234	Biological process	negative regulation of apoptotic signaling pathway
GO_0097194	Biological process	execution phase of apoptosis
GO_0060402	Biological process	calcium ion transport into cytosol
GO_0033137	Biological process	negative regulation of peptidyl-serine phosphorylation
GO_0032091	Biological process	negative regulation of protein binding
GO_0002904	Biological process	positive regulation of B cell apoptotic process
GO_0035234	Biological process	ectopic germ cell programmed cell death
GO_0051726	Biological process	regulation of cell cycle
GO_0042475	Biological process	odontogenesis of dentin-containing tooth
GO_0008635	Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO_0090200	Biological process	positive regulation of release of cytochrome c from mitochondria
GO_0097190	Biological process	apoptotic signaling pathway
GO_0002358	Biological process	B cell homeostatic proliferation
GO_0048515	Biological process	spermatid differentiation
GO_0034644	Biological process	cellular response to UV
GO_1903896	Biological process	positive regulation of IRE1-mediated unfolded protein response
GO_2001244	Biological process	positive regulation of intrinsic apoptotic signaling pathway
GO_0032976	Biological process	release of matrix enzymes from mitochondria
GO_0060058	Biological process	positive regulation of apoptotic process involved in mammary gland involution
GO_0001822	Biological process	kidney development
GO_0070242	Biological process	thymocyte apoptotic process
GO_0097193	Biological process	intrinsic apoptotic signaling pathway
GO_0060011	Biological process	Sertoli cell proliferation
GO_0042981	Biological process	regulation of apoptotic process
GO_0007281	Biological process	germ cell development
GO_0046666	Biological process	retinal cell programmed cell death
GO_0010248	Biological process	establishment or maintenance of transmembrane electrochemical gradient
GO_0008630	Biological process	intrinsic apoptotic signaling pathway in response to DNA damage
GO_0051204	Biological process	protein insertion into mitochondrial membrane
GO_0097191	Biological process	extrinsic apoptotic signaling pathway
GO_0070059	Biological process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0060057	Biological process	apoptotic process involved in mammary gland involution
GO_0006687	Biological process	glycosphingolipid metabolic process
GO_0034620	Biological process	cellular response to unfolded protein
GO_0048597	Biological process	post-embryonic camera-type eye morphogenesis
GO_0008625	Biological process	extrinsic apoptotic signaling pathway via death domain receptors
GO_0008053	Biological process	mitochondrial fusion
GO_0001782	Biological process	B cell homeostasis
GO_0048087	Biological process	positive regulation of developmental pigmentation
GO_2000673	Biological process	positive regulation of motor neuron apoptotic process
GO_1904037	Biological process	positive regulation of epithelial cell apoptotic process
GO_1902263	Biological process	apoptotic process involved in embryonic digit morphogenesis
GO_0043653	Biological process	mitochondrial fragmentation involved in apoptotic process
GO_0097435	Biological process	supramolecular fiber organization
GO_0045136	Biological process	development of secondary sexual characteristics
GO_0072332	Biological process	intrinsic apoptotic signaling pathway by p53 class mediator
GO_0001836	Biological process	release of cytochrome c from mitochondria
GO_1904019	Biological process	epithelial cell apoptotic process
GO_0051281	Biological process	positive regulation of release of sequestered calcium ion into cytosol
GO_0002352	Biological process	B cell negative selection
GO_0009636	Biological process	response to toxic substance
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0021854	Biological process	hypothalamus development
GO_0002262	Biological process	myeloid cell homeostasis
GO_0033599	Biological process	regulation of mammary gland epithelial cell proliferation
GO_0010524	Biological process	positive regulation of calcium ion transport into cytosol
GO_0001783	Biological process	B cell apoptotic process
GO_0032471	Biological process	negative regulation of endoplasmic reticulum calcium ion concentration
GO_0048678	Biological process	response to axon injury
GO_0006808	Biological process	regulation of nitrogen utilization
GO_0060041	Biological process	retina development in camera-type eye
GO_0051209	Biological process	release of sequestered calcium ion into cytosol
GO_0043525	Biological process	positive regulation of neuron apoptotic process
GO_0048873	Biological process	homeostasis of number of cells within a tissue
GO_0051881	Biological process	regulation of mitochondrial membrane potential
GO_0098586	Biological process	cellular response to virus
GO_0008637	Biological process	apoptotic mitochondrial changes
GO_1902110	Biological process	positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO_0009566	Biological process	fertilization
GO_1990117	Biological process	B cell receptor apoptotic signaling pathway
GO_0097049	Biological process	motor neuron apoptotic process
GO_0006915	Biological process	apoptotic process
GO_0021987	Biological process	cerebral cortex development
GO_2000243	Biological process	positive regulation of reproductive process
GO_0032469	Biological process	endoplasmic reticulum calcium ion homeostasis
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005757	Cellular component	mitochondrial permeability transition pore complex
GO_0071944	Cellular component	cell periphery
GO_0097136	Cellular component	Bcl-2 family protein complex
GO_0005634	Cellular component	nucleus
GO_0070062	Cellular component	extracellular exosome
GO_0046930	Cellular component	pore complex
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005737	Cellular component	cytoplasm
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0097145	Cellular component	BAK complex
GO_0005635	Cellular component	nuclear envelope
GO_0005829	Cellular component	cytosol
GO_0097144	Cellular component	BAX complex
GO_0015267	Molecular function	channel activity
GO_0042802	Molecular function	identical protein binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0051400	Molecular function	BH domain binding
GO_0051434	Molecular function	BH3 domain binding
GO_0030544	Molecular function	Hsp70 protein binding
GO_0008289	Molecular function	lipid binding
GO_0005515	Molecular function	protein binding
GO_0042803	Molecular function	protein homodimerization activity

IV. Literature review

[source]

Gene name	BAX
Protein name	Bax protein BCL2 associated X, apoptosis regulator (BCL2-associated X protein theta) BCL2 associated X, apoptosis regulator BCL2-associated X protein transcript variant delta2 BCL2-associated X protein Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)
Synonyms	BCL2L4
Description	FUNCTION: Plays a role in the mitochondrial apoptotic process . Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) . Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis . Promotes activation of CASP3, and thereby apoptosis . .
Accessions	I6LPK7 Q5ZPJ1 Q07812 K4JQN1 Q8WXU1 ENST00000354470.7 [Q07812-4] ENST00000415969.6 [Q07812-8] ENST00000293288.12 [Q07812-2] ENST00000345358.12 [Q07812-1] Q5ZPJ0 H0YA56 ENST00000539787.2 ENST00000506183.5 ENST00000356483.8 [Q07812-5] ENST00000515540.5 [Q07812-3]

BAX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review