Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell of lymphatic vessel | 12 studies | 32% ± 12% | |
| ciliated cell | 9 studies | 27% ± 12% | |
| glutamatergic neuron | 6 studies | 42% ± 19% | |
| GABAergic neuron | 5 studies | 46% ± 18% | |
| oligodendrocyte precursor cell | 4 studies | 23% ± 6% | |
| astrocyte | 4 studies | 38% ± 15% | |
| interneuron | 4 studies | 45% ± 13% | |
| macrophage | 3 studies | 19% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 6 studies | 33% ± 18% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 99% | 183.98 | 954 / 966 | 93% | 5.58 | 491 / 527 |
| lung | 100% | 258.52 | 578 / 578 | 87% | 3.49 | 1008 / 1155 |
| kidney | 100% | 129.72 | 89 / 89 | 85% | 3.16 | 768 / 901 |
| liver | 100% | 170.61 | 226 / 226 | 85% | 2.29 | 345 / 406 |
| stomach | 87% | 76.72 | 312 / 359 | 95% | 5.99 | 271 / 286 |
| esophagus | 93% | 109.52 | 1345 / 1445 | 85% | 3.50 | 156 / 183 |
| prostate | 99% | 156.34 | 243 / 245 | 77% | 2.01 | 388 / 502 |
| pancreas | 73% | 59.81 | 240 / 328 | 93% | 3.52 | 165 / 178 |
| bladder | 95% | 123.95 | 20 / 21 | 70% | 2.82 | 354 / 504 |
| uterus | 95% | 85.73 | 161 / 170 | 68% | 2.07 | 314 / 459 |
| thymus | 99% | 147.98 | 649 / 653 | 55% | 1.15 | 333 / 605 |
| skin | 99% | 238.51 | 1796 / 1809 | 49% | 1.26 | 230 / 472 |
| breast | 93% | 105.01 | 428 / 459 | 47% | 1.04 | 520 / 1118 |
| adrenal gland | 97% | 78.36 | 249 / 258 | 37% | 0.70 | 84 / 230 |
| ovary | 89% | 66.54 | 160 / 180 | 31% | 0.63 | 135 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 5.96 | 29 / 29 |
| spleen | 100% | 174.05 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 96% | 136.02 | 1150 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 89% | 90.80 | 1185 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 78% | 3.05 | 35 / 45 |
| brain | 34% | 23.23 | 907 / 2642 | 30% | 0.68 | 212 / 705 |
| heart | 39% | 22.12 | 333 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 25% | 166.44 | 232 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.12 | 6 / 80 |
| muscle | 3% | 1.35 | 27 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0097191 | Biological process | extrinsic apoptotic signaling pathway |
| GO_0035265 | Biological process | organ growth |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0032722 | Biological process | positive regulation of chemokine production |
| GO_0045582 | Biological process | positive regulation of T cell differentiation |
| GO_0009887 | Biological process | animal organ morphogenesis |
| GO_0001961 | Biological process | positive regulation of cytokine-mediated signaling pathway |
| GO_0038111 | Biological process | interleukin-7-mediated signaling pathway |
| GO_0045579 | Biological process | positive regulation of B cell differentiation |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0048873 | Biological process | homeostasis of number of cells within a tissue |
| GO_0006959 | Biological process | humoral immune response |
| GO_0050730 | Biological process | regulation of peptidyl-tyrosine phosphorylation |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0030890 | Biological process | positive regulation of B cell proliferation |
| GO_0045453 | Biological process | bone resorption |
| GO_0002360 | Biological process | T cell lineage commitment |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0042100 | Biological process | B cell proliferation |
| GO_2001240 | Biological process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO_0046622 | Biological process | positive regulation of organ growth |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0005139 | Molecular function | interleukin-7 receptor binding |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | IL7 |
| Protein name | IL7 nirs variant 3 (Interleukin 7) IL7 nirs variant 5 Interleukin-7 Interleukin-7 (IL-7) |
| Synonyms | |
| Description | FUNCTION: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis . Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG . Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5 . . FUNCTION: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. . |
| Accessions | P13232 ENST00000520317.1 ENST00000520215.5 ENST00000520269.5 [P13232-2] Q5FBX5 ENST00000541183.2 Q5FBY8 A0A0A0MTG5 Q5FBY6 ENST00000518982.5 Q5FBY3 D0EYG7 ENST00000263851.9 [P13232-1] ENST00000379113.6 |
