TGFB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060312Biological processregulation of blood vessel remodeling
GO_0055091Biological processphospholipid homeostasis
GO_0010742Biological processmacrophage derived foam cell differentiation
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0006611Biological processprotein export from nucleus
GO_0071260Biological processcellular response to mechanical stimulus
GO_0045786Biological processnegative regulation of cell cycle
GO_0051247Biological processpositive regulation of protein metabolic process
GO_0046716Biological processmuscle cell cellular homeostasis
GO_0014008Biological processpositive regulation of microglia differentiation
GO_0042098Biological processT cell proliferation
GO_0045662Biological processnegative regulation of myoblast differentiation
GO_0002062Biological processchondrocyte differentiation
GO_0006796Biological processphosphate-containing compound metabolic process
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0051152Biological processpositive regulation of smooth muscle cell differentiation
GO_0036446Biological processmyofibroblast differentiation
GO_0043537Biological processnegative regulation of blood vessel endothelial cell migration
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0045066Biological processregulatory T cell differentiation
GO_0051402Biological processneuron apoptotic process
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0070168Biological processnegative regulation of biomineral tissue development
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0030334Biological processregulation of cell migration
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0043129Biological processsurfactant homeostasis
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_2000636Biological processpositive regulation of primary miRNA processing
GO_0000902Biological processcell morphogenesis
GO_0051280Biological processnegative regulation of release of sequestered calcium ion into cytosol
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0070306Biological processlens fiber cell differentiation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_2000353Biological processpositive regulation of endothelial cell apoptotic process
GO_0032740Biological processpositive regulation of interleukin-17 production
GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0050673Biological processepithelial cell proliferation
GO_0030279Biological processnegative regulation of ossification
GO_0043029Biological processT cell homeostasis
GO_0070723Biological processresponse to cholesterol
GO_0072089Biological processstem cell proliferation
GO_0051781Biological processpositive regulation of cell division
GO_0002244Biological processhematopoietic progenitor cell differentiation
GO_0001657Biological processureteric bud development
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0071333Biological processcellular response to glucose stimulus
GO_1904894Biological processpositive regulation of receptor signaling pathway via STAT
GO_0048298Biological processpositive regulation of isotype switching to IgA isotypes
GO_1990314Biological processcellular response to insulin-like growth factor stimulus
GO_0060751Biological processbranch elongation involved in mammary gland duct branching
GO_0002028Biological processregulation of sodium ion transport
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0007219Biological processNotch signaling pathway
GO_0042552Biological processmyelination
GO_0042482Biological processpositive regulation of odontogenesis
GO_0010629Biological processnegative regulation of gene expression
GO_0060744Biological processmammary gland branching involved in thelarche
GO_0085029Biological processextracellular matrix assembly
GO_0048535Biological processlymph node development
GO_0032667Biological processregulation of interleukin-23 production
GO_0002069Biological processcolumnar/cuboidal epithelial cell maturation
GO_0010763Biological processpositive regulation of fibroblast migration
GO_1902894Biological processnegative regulation of miRNA transcription
GO_0010628Biological processpositive regulation of gene expression
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0060391Biological processpositive regulation of SMAD protein signal transduction
GO_0031536Biological processpositive regulation of exit from mitosis
GO_0030214Biological processhyaluronan catabolic process
GO_0007565Biological processfemale pregnancy
GO_1904018Biological processpositive regulation of vasculature development
GO_0055010Biological processventricular cardiac muscle tissue morphogenesis
GO_0045216Biological processcell-cell junction organization
GO_2000343Biological processpositive regulation of chemokine (C-X-C motif) ligand 2 production
GO_1990402Biological processembryonic liver development
GO_1901203Biological processpositive regulation of extracellular matrix assembly
GO_0060364Biological processfrontal suture morphogenesis
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0097421Biological processliver regeneration
GO_0032967Biological processpositive regulation of collagen biosynthetic process
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0001843Biological processneural tube closure
GO_0048565Biological processdigestive tract development
GO_0061035Biological processregulation of cartilage development
GO_0032930Biological processpositive regulation of superoxide anion generation
GO_0010467Biological processgene expression
GO_0050729Biological processpositive regulation of inflammatory response
GO_0032700Biological processnegative regulation of interleukin-17 production
GO_0071479Biological processcellular response to ionizing radiation
GO_0010716Biological processnegative regulation of extracellular matrix disassembly
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0032801Biological processreceptor catabolic process
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0030308Biological processnegative regulation of cell growth
GO_0007406Biological processnegative regulation of neuroblast proliferation
GO_0022408Biological processnegative regulation of cell-cell adhesion
GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0048642Biological processnegative regulation of skeletal muscle tissue development
GO_0014003Biological processoligodendrocyte development
GO_0032355Biological processresponse to estradiol
GO_0031293Biological processmembrane protein intracellular domain proteolysis
GO_0030316Biological processosteoclast differentiation
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0002460Biological processadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO_0043536Biological processpositive regulation of blood vessel endothelial cell migration
GO_0050921Biological processpositive regulation of chemotaxis
GO_0002248Biological processconnective tissue replacement involved in inflammatory response wound healing
GO_0070173Biological processregulation of enamel mineralization
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0035902Biological processresponse to immobilization stress
GO_0003179Biological processheart valve morphogenesis
GO_0001570Biological processvasculogenesis
GO_0003180Biological processaortic valve morphogenesis
GO_1902462Biological processpositive regulation of mesenchymal stem cell proliferation
GO_0061298Biological processretina vasculature development in camera-type eye
GO_0002040Biological processsprouting angiogenesis
GO_1902074Biological processresponse to salt
GO_0050714Biological processpositive regulation of protein secretion
GO_0002513Biological processtolerance induction to self antigen
GO_0007492Biological processendoderm development
GO_0002859Biological processnegative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO_0071895Biological processodontoblast differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0010575Biological processpositive regulation of vascular endothelial growth factor production
GO_0090190Biological processpositive regulation of branching involved in ureteric bud morphogenesis
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0060325Biological processface morphogenesis
GO_0009611Biological processresponse to wounding
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0042127Biological processregulation of cell population proliferation
GO_0007435Biological processsalivary gland morphogenesis
GO_0016202Biological processregulation of striated muscle tissue development
GO_0032570Biological processresponse to progesterone
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0033280Biological processresponse to vitamin D
GO_0048286Biological processlung alveolus development
GO_0061520Biological processLangerhans cell differentiation
GO_0071456Biological processcellular response to hypoxia
GO_0060762Biological processregulation of branching involved in mammary gland duct morphogenesis
GO_0050832Biological processdefense response to fungus
GO_0001837Biological processepithelial to mesenchymal transition
GO_0060435Biological processbronchiole development
GO_0007507Biological processheart development
GO_0006754Biological processATP biosynthetic process
GO_2000727Biological processpositive regulation of cardiac muscle cell differentiation
GO_1902893Biological processregulation of miRNA transcription
GO_0048839Biological processinner ear development
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0098586Biological processcellular response to virus
GO_0050765Biological processnegative regulation of phagocytosis
GO_0071404Biological processcellular response to low-density lipoprotein particle stimulus
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0030335Biological processpositive regulation of cell migration
GO_0071677Biological processpositive regulation of mononuclear cell migration
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0045596Biological processnegative regulation of cell differentiation
GO_0010936Biological processnegative regulation of macrophage cytokine production
GO_1905005Biological processregulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO_0034616Biological processresponse to laminar fluid shear stress
GO_1900126Biological processnegative regulation of hyaluronan biosynthetic process
GO_0008354Biological processgerm cell migration
GO_0021915Biological processneural tube development
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0045591Biological processpositive regulation of regulatory T cell differentiation
GO_0042306Biological processregulation of protein import into nucleus
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0035307Biological processpositive regulation of protein dephosphorylation
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_1903077Biological processnegative regulation of protein localization to plasma membrane
GO_0043117Biological processpositive regulation of vascular permeability
GO_0043025Cellular componentneuronal cell body
GO_0009986Cellular componentcell surface
GO_0005634Cellular componentnucleus
GO_0005576Cellular componentextracellular region
GO_0031093Cellular componentplatelet alpha granule lumen
GO_0005902Cellular componentmicrovillus
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0031012Cellular componentextracellular matrix
GO_0072562Cellular componentblood microparticle
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0005796Cellular componentGolgi lumen
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0042802Molecular functionidentical protein binding
GO_0034714Molecular functiontype III transforming growth factor beta receptor binding
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0035800Molecular functiondeubiquitinase activator activity
GO_0003823Molecular functionantigen binding
GO_0005125Molecular functioncytokine activity
GO_0019899Molecular functionenzyme binding
GO_0005114Molecular functiontype II transforming growth factor beta receptor binding
GO_0005515Molecular functionprotein binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0008083Molecular functiongrowth factor activity
GO_0034713Molecular functiontype I transforming growth factor beta receptor binding

IV. Literature review

[source]
Gene nameTGFB1
Protein nameTransforming growth factor beta
Transforming growth factor beta 1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
Transforming growth factor, beta 1
SynonymsTGFB
DescriptionFUNCTION: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. .

FUNCTION: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. .; FUNCTION: [Latency-associated peptide]: Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix . Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1 . Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia (Probable). Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs) . Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1 . .; FUNCTION: [Transforming growth factor beta-1]: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix . At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus . TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1 . Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal . While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules' (By similarity). Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner (By similarity). At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development (By similarity). At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) . Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus . Positively regulates odontoblastic differentiation in dental papilla cells, via promotion of IPO7-mediated translocation of phosphorylated SMAD2 to the nucleus and subsequent transcription of target genes (By similarity). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types . .

FUNCTION: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. .

AccessionsENST00000600196.2
Q49IK8
ENST00000677934.1
A0A078BC11
Q49IL8
A0A499FJK2
A0A078BFK3
Q7Z487
Q86YU2
A0A078BCJ0
Q7Z488
A0A7I2YQL8
A0A078BCH8
A0A078BBI5
B2C8Z3
A0A7I2V5Z9
P01137
ENST00000221930.6