ACVR1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0032924Biological processactivin receptor signaling pathway
GO_0007178Biological processcell surface receptor protein serine/threonine kinase signaling pathway
GO_0001701Biological processin utero embryonic development
GO_0010629Biological processnegative regulation of gene expression
GO_1901165Biological processpositive regulation of trophoblast cell migration
GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0032927Biological processpositive regulation of activin receptor signaling pathway
GO_0071363Biological processcellular response to growth factor stimulus
GO_0006355Biological processregulation of DNA-templated transcription
GO_0001942Biological processhair follicle development
GO_0038092Biological processnodal signaling pathway
GO_0045648Biological processpositive regulation of erythrocyte differentiation
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0007399Biological processnervous system development
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0030308Biological processnegative regulation of cell growth
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0048179Cellular componentactivin receptor complex
GO_0046332Molecular functionSMAD binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0048185Molecular functionactivin binding
GO_0004675Molecular functiontransmembrane receptor protein serine/threonine kinase activity
GO_0017002Molecular functionactivin receptor activity
GO_0019838Molecular functiongrowth factor binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0034711Molecular functioninhibin binding
GO_0070411Molecular functionI-SMAD binding
GO_0005515Molecular functionprotein binding
GO_0016361Molecular functionactivin receptor activity, type I

IV. Literature review

[source]
Gene nameACVR1B
Protein nameActivin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
Activin A receptor type 1B
SynonymsALK4
ACVRLK4
DescriptionFUNCTION: Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. .

AccessionsF5H5Q2
ENST00000257963.9 [P36896-1]
ENST00000536420.5
ENST00000415850.6 [P36896-3]
ENST00000426655.6 [P36896-2]
ENST00000541224.5 [P36896-4]
P36896
ENST00000542485.1 [P36896-5]