CASP8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0032355Biological processresponse to estradiol
GO_0001525Biological processangiogenesis
GO_0097190Biological processapoptotic signaling pathway
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0045651Biological processpositive regulation of macrophage differentiation
GO_0071260Biological processcellular response to mechanical stimulus
GO_0007507Biological processheart development
GO_0045862Biological processpositive regulation of proteolysis
GO_0030225Biological processmacrophage differentiation
GO_0030101Biological processnatural killer cell activation
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0036462Biological processTRAIL-activated apoptotic signaling pathway
GO_0070269Biological processpyroptotic inflammatory response
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0045471Biological processresponse to ethanol
GO_0034612Biological processresponse to tumor necrosis factor
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0097202Biological processactivation of cysteine-type endopeptidase activity
GO_0045088Biological processregulation of innate immune response
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0060546Biological processnegative regulation of necroptotic process
GO_0030335Biological processpositive regulation of cell migration
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0097264Biological processself proteolysis
GO_0042113Biological processB cell activation
GO_0006508Biological processproteolysis
GO_0001817Biological processregulation of cytokine production
GO_0097194Biological processexecution phase of apoptosis
GO_0006915Biological processapoptotic process
GO_0051603Biological processproteolysis involved in protein catabolic process
GO_0032025Biological processresponse to cobalt ion
GO_0060715Biological processsyncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO_0043065Biological processpositive regulation of apoptotic process
GO_0042110Biological processT cell activation
GO_0071407Biological processcellular response to organic cyclic compound
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0032496Biological processresponse to lipopolysaccharide
GO_0051604Biological processprotein maturation
GO_0097342Cellular componentripoptosome
GO_0005856Cellular componentcytoskeleton
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0031265Cellular componentCD95 death-inducing signaling complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0044297Cellular componentcell body
GO_0031264Cellular componentdeath-inducing signaling complex
GO_0030027Cellular componentlamellipodium
GO_0008233Molecular functionpeptidase activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0097153Molecular functioncysteine-type endopeptidase activity involved in apoptotic process
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0097110Molecular functionscaffold protein binding
GO_0097199Molecular functioncysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO_0005123Molecular functiondeath receptor binding
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0008234Molecular functioncysteine-type peptidase activity
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0035877Molecular functiondeath effector domain binding

IV. Literature review

[source]
Gene nameCASP8
Protein nameCaspase 8 splice variant
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Caspase 8
CASP8 protein
Caspase 8 isoform C
Caspase-8
SynonymsMCH5
DescriptionFUNCTION: Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood . Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death . Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 . Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A . The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation . The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases . Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC . In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response . Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis . Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways . Cleaves PARP1 and PARP2 . Independent of its protease activity, promotes cell migration following phosphorylation at Tyr-380 . .; FUNCTION: [Isoform 5]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. .; FUNCTION: [Isoform 6]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. .; FUNCTION: [Isoform 7]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade . .; FUNCTION: [Isoform 8]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. .

AccessionsENST00000447616.6 [Q14790-6]
E7ETB7
E7EQ01
ENST00000429881.2
C9JB29
ENST00000437283.5
ENST00000392258.7 [Q14790-5]
ENST00000696087.1 [Q14790-2]
E7EVN1
ENST00000264275.9 [Q14790-4]
ENST00000392263.6 [Q14790-2]
ENST00000413726.5
ENST00000440732.5
ENST00000447616.5
ENST00000696085.1
ENST00000696067.1 [Q14790-1]
ENST00000432109.6 [Q14790-1]
ENST00000413726.6 [Q14790-1]
ENST00000444430.3 [Q14790-3]
ENST00000696068.1 [Q14790-6]
A0A8Q3WKY8
Q6NVI2
ENST00000339403.6
Q14790
ENST00000673742.1 [Q14790-1]
ENST00000444430.2
B5BU46
ENST00000323492.11 [Q14790-2]
ENST00000358485.8 [Q14790-9]
B6CGU5
ENST00000450491.6
ENST00000696069.1
ENST00000440732.6 [Q14790-1]
H7C0E2
F8WF39
A0A8Q3SI66
E7EQ06
A0A8Q3SID9