NDUFA13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0097190Biological processapoptotic signaling pathway
GO_0042776Biological processproton motive force-driven mitochondrial ATP synthesis
GO_0035458Biological processcellular response to interferon-beta
GO_0072593Biological processreactive oxygen species metabolic process
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0032981Biological processmitochondrial respiratory chain complex I assembly
GO_2001243Biological processnegative regulation of intrinsic apoptotic signaling pathway
GO_0009060Biological processaerobic respiration
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_1900119Biological processpositive regulation of execution phase of apoptosis
GO_0030308Biological processnegative regulation of cell growth
GO_0045039Biological processprotein insertion into mitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0005654Cellular componentnucleoplasm
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005737Cellular componentcytoplasm
GO_0005746Cellular componentmitochondrial respirasome
GO_0045271Cellular componentrespiratory chain complex I
GO_0061133Molecular functionendopeptidase activator activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNDUFA13
Protein nameNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Cell death regulatory protein GRIM-19) (Complex I-B16.6) (CI-B16.6) (Gene associated with retinoic and interferon-induced mortality 19 protein) (GRIM-19) (Gene associated with retinoic and IFN-induced mortality 19 protein) (NADH-ubiquinone oxidoreductase B16.6 subunit)
SynonymsGRIM19
CDA016
CGI-39
DescriptionFUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis . Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone . Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes . .

FUNCTION: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. .

FUNCTION: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. .

FUNCTION: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. .

FUNCTION: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. .

AccessionsU3KQP3
K7EP87
ENST00000502506.6
K7EJE1
ENST00000503283.5
ENST00000507754.9 [Q9P0J0-1]
ENST00000428459.6
Q9P0J0
ENST00000606722.1
B4DEZ3