WWOX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_2001238Biological processpositive regulation of extrinsic apoptotic signaling pathway
GO_0001649Biological processosteoblast differentiation
GO_0030178Biological processnegative regulation of Wnt signaling pathway
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0016055Biological processWnt signaling pathway
GO_2001241Biological processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0048705Biological processskeletal system morphogenesis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005902Cellular componentmicrovillus
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0005764Cellular componentlysosome
GO_0005794Cellular componentGolgi apparatus
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0016491Molecular functionoxidoreductase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWWOX
Protein nameWWOX isoform 4
WWOX isoform 5
WWOX isoform 3
WWOX isoform 7
WW domain-containing oxidoreductase
WW domain containing oxidoreductase
WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase) (Short chain dehydrogenase/reductase family 41C member 1)
WWOX isoform 8
SynonymsWOX1
SDR41C1
FOR
DescriptionFUNCTION: Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. .

AccessionsENST00000569818.1 [Q9NZC7-4]
ENST00000406884.6 [Q9NZC7-5]
ENST00000355860.7 [Q9NZC7-3]
A0A1Y0ZSQ6
ENST00000408984.7 [Q9NZC7-2]
A0A411HBF4
A0A411HBG6
ENST00000683929.1
A0A1Y0ZJ50
A0A411HBH2
ENST00000627394.3
A0A411HBF5
A0A411HBD8
F5H3R5
A0A804HJX9
ENST00000539474.6
ENST00000566780.6 [Q9NZC7-1]
A0A411HBG5
ENST00000402655.6 [Q9NZC7-6]
Q9NZC7
A0A411HBC7
ENST00000569332.5
H3BMD1
A0A411HBG3
ENST00000566662.5
A0A0D9SER1