I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 9 studies | 26% ± 9% | |
| alveolar macrophage | 8 studies | 44% ± 13% | |
| macrophage | 6 studies | 27% ± 8% | |
| smooth muscle cell | 5 studies | 24% ± 5% | |
| pericyte | 3 studies | 20% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 9 studies | 26% ± 9% | |
| alveolar macrophage | 8 studies | 44% ± 13% | |
| macrophage | 6 studies | 27% ± 8% | |
| smooth muscle cell | 5 studies | 24% ± 5% | |
| pericyte | 3 studies | 20% ± 2% |
Insufficient scRNA-seq data for expression of INHBA at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 97% | 2093.25 | 559 / 578 | 84% | 23.94 | 975 / 1155 |
| esophagus | 65% | 1085.66 | 941 / 1445 | 87% | 42.71 | 160 / 183 |
| ovary | 94% | 599.28 | 169 / 180 | 43% | 9.09 | 183 / 430 |
| uterus | 82% | 838.35 | 139 / 170 | 53% | 12.77 | 243 / 459 |
| breast | 40% | 199.74 | 182 / 459 | 92% | 37.01 | 1033 / 1118 |
| liver | 87% | 872.62 | 197 / 226 | 31% | 3.90 | 125 / 406 |
| skin | 79% | 1489.90 | 1437 / 1809 | 26% | 8.33 | 122 / 472 |
| stomach | 24% | 149.61 | 87 / 359 | 80% | 22.91 | 230 / 286 |
| bladder | 38% | 176.52 | 8 / 21 | 65% | 17.98 | 327 / 504 |
| blood vessel | 100% | 4666.28 | 1331 / 1335 | 0% | 0 | 0 / 0 |
| intestine | 22% | 126.51 | 215 / 966 | 75% | 19.29 | 394 / 527 |
| prostate | 60% | 416.88 | 147 / 245 | 34% | 4.12 | 171 / 502 |
| pancreas | 4% | 18.60 | 13 / 328 | 90% | 42.72 | 160 / 178 |
| kidney | 37% | 272.80 | 33 / 89 | 42% | 6.70 | 375 / 901 |
| thymus | 39% | 196.35 | 255 / 653 | 31% | 4.39 | 186 / 605 |
| tonsil | 0% | 0 | 0 / 0 | 56% | 16.96 | 25 / 45 |
| heart | 53% | 650.07 | 455 / 861 | 0% | 0 | 0 / 0 |
| adipose | 33% | 223.45 | 398 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 16% | 80.91 | 42 / 258 | 10% | 1.79 | 23 / 230 |
| brain | 17% | 107.31 | 439 / 2642 | 6% | 1.10 | 44 / 705 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 2.04 | 3 / 29 |
| peripheral blood | 10% | 45.84 | 89 / 929 | 0% | 0 | 0 / 0 |
| spleen | 3% | 10.95 | 7 / 241 | 0% | 0 | 0 / 0 |
| muscle | 2% | 13.13 | 19 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0097191 | Biological process | extrinsic apoptotic signaling pathway |
| GO_0046880 | Biological process | regulation of follicle-stimulating hormone secretion |
| GO_0006366 | Biological process | transcription by RNA polymerase II |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0002244 | Biological process | hematopoietic progenitor cell differentiation |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0032924 | Biological process | activin receptor signaling pathway |
| GO_0042701 | Biological process | progesterone secretion |
| GO_0060279 | Biological process | positive regulation of ovulation |
| GO_0042476 | Biological process | odontogenesis |
| GO_0051247 | Biological process | positive regulation of protein metabolic process |
| GO_0021773 | Biological process | striatal medium spiny neuron differentiation |
| GO_0071372 | Biological process | cellular response to follicle-stimulating hormone stimulus |
| GO_0042541 | Biological process | hemoglobin biosynthetic process |
| GO_0001541 | Biological process | ovarian follicle development |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0035987 | Biological process | endodermal cell differentiation |
| GO_1904385 | Biological process | cellular response to angiotensin |
| GO_0060391 | Biological process | positive regulation of SMAD protein signal transduction |
| GO_0097154 | Biological process | GABAergic neuron differentiation |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0048333 | Biological process | mesodermal cell differentiation |
| GO_0090650 | Biological process | cellular response to oxygen-glucose deprivation |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0042326 | Biological process | negative regulation of phosphorylation |
| GO_0060936 | Biological process | cardiac fibroblast cell development |
| GO_0046882 | Biological process | negative regulation of follicle-stimulating hormone secretion |
| GO_0030218 | Biological process | erythrocyte differentiation |
| GO_0060395 | Biological process | SMAD protein signal transduction |
| GO_0060021 | Biological process | roof of mouth development |
| GO_0045650 | Biological process | negative regulation of macrophage differentiation |
| GO_0032967 | Biological process | positive regulation of collagen biosynthetic process |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0045945 | Biological process | positive regulation of transcription by RNA polymerase III |
| GO_0030154 | Biological process | cell differentiation |
| GO_0071397 | Biological process | cellular response to cholesterol |
| GO_1904044 | Biological process | response to aldosterone |
| GO_0001942 | Biological process | hair follicle development |
| GO_0045648 | Biological process | positive regulation of erythrocyte differentiation |
| GO_0030308 | Biological process | negative regulation of cell growth |
| GO_0008584 | Biological process | male gonad development |
| GO_2000134 | Biological process | negative regulation of G1/S transition of mitotic cell cycle |
| GO_0032689 | Biological process | negative regulation of type II interferon production |
| GO_0006914 | Biological process | autophagy |
| GO_0046881 | Biological process | positive regulation of follicle-stimulating hormone secretion |
| GO_2001241 | Biological process | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0061029 | Biological process | eyelid development in camera-type eye |
| GO_0009611 | Biological process | response to wounding |
| GO_0045578 | Biological process | negative regulation of B cell differentiation |
| GO_0007399 | Biological process | nervous system development |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0006952 | Biological process | defense response |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0071456 | Biological process | cellular response to hypoxia |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0043509 | Cellular component | activin A complex |
| GO_0043512 | Cellular component | inhibin A complex |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0070699 | Molecular function | type II activin receptor binding |
| GO_0017046 | Molecular function | peptide hormone binding |
| GO_0005179 | Molecular function | hormone activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0005125 | Molecular function | cytokine activity |
| Gene name | INHBA |
| Protein name | Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF) Inhibin beta A chain (Activin beta-A chain) |
| Synonyms | hCG_17267 tcag7.474 |
| Description | FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. . FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. |
| Accessions | ENST00000638023.1 ENST00000242208.5 ENST00000442711.1 A4D1W7 P08476 |
