RB1CC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0034517Biological processribophagy
GO_0030242Biological processautophagy of peroxisome
GO_1903059Biological processregulation of protein lipidation
GO_0007507Biological processheart development
GO_0000045Biological processautophagosome assembly
GO_0046330Biological processpositive regulation of JNK cascade
GO_0034727Biological processpiecemeal microautophagy of the nucleus
GO_0001889Biological processliver development
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0010508Biological processpositive regulation of autophagy
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0000422Biological processautophagy of mitochondrion
GO_0061709Biological processreticulophagy
GO_0006914Biological processautophagy
GO_0045793Biological processpositive regulation of cell size
GO_0061723Biological processglycophagy
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0034045Cellular componentphagophore assembly site membrane
GO_0005764Cellular componentlysosome
GO_0000421Cellular componentautophagosome membrane
GO_0005829Cellular componentcytosol
GO_1990316Cellular componentAtg1/ULK1 kinase complex
GO_0000407Cellular componentphagophore assembly site
GO_0031965Cellular componentnuclear membrane
GO_0060090Molecular functionmolecular adaptor activity
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRB1CC1
Protein nameRB1 inducible coiled-coil 1
RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200)
SynonymsRBICC
KIAA0203
DescriptionFUNCTION: Involved in autophagy . Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 . Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways . Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor . Is a potent regulator of the RB1 pathway through induction of RB1 expression . Plays a crucial role in muscular differentiation . Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). .

AccessionsE5RJC1
H0YC28
E5RH44
H0YC30
ENST00000517963.1
ENST00000519912.1
ENST00000435644.6 [Q8TDY2-2]
E5RH63
Q8TDY2
ENST00000025008.10 [Q8TDY2-1]
ENST00000518468.1
ENST00000518211.1
ENST00000518710.5
E5RHX0
ENST00000523594.1