HIPK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0060059Biological processembryonic retina morphogenesis in camera-type eye
GO_0007224Biological processsmoothened signaling pathway
GO_0008283Biological processcell population proliferation
GO_0034333Biological processadherens junction assembly
GO_0048596Biological processembryonic camera-type eye morphogenesis
GO_0045766Biological processpositive regulation of angiogenesis
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0001654Biological processeye development
GO_0072577Biological processendothelial cell apoptotic process
GO_0030182Biological processneuron differentiation
GO_0060216Biological processdefinitive hemopoiesis
GO_0009952Biological processanterior/posterior pattern specification
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0060235Biological processlens induction in camera-type eye
GO_0061072Biological processiris morphogenesis
GO_0006468Biological processprotein phosphorylation
GO_0010842Biological processretina layer formation
GO_0016607Cellular componentnuclear speck
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHIPK1
Protein nameHomeodomain interacting protein kinase 1
Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2)
SynonymsNBAK2
KIAA0630
MYAK
DescriptionFUNCTION: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN . .

AccessionsD6RC95
ENST00000626993.2
D6RF28
ENST00000369553.5 [Q86Z02-4]
Q86Z02
ENST00000426820.7 [Q86Z02-1]
J3KP92
ENST00000369559.8 [Q86Z02-2]
ENST00000340480.8 [Q86Z02-3]
ENST00000369555.6
ENST00000369558.5 [Q86Z02-1]
Q5SQL3
ENST00000514621.5
ENST00000361587.3
ENST00000503968.1
ENST00000369561.8
H3BLW0