FAS report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FAS at tissue level.

III. Associated gene sets

GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0071260Biological processcellular response to mechanical stimulus
GO_0007165Biological processsignal transduction
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0032872Biological processregulation of stress-activated MAPK cascade
GO_0065003Biological processprotein-containing complex assembly
GO_0006955Biological processimmune response
GO_0042981Biological processregulation of apoptotic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_2001269Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO_0034198Biological processcellular response to amino acid starvation
GO_0006924Biological processactivation-induced cell death of T cells
GO_0071455Biological processcellular response to hyperoxia
GO_0097049Biological processmotor neuron apoptotic process
GO_0097527Biological processnecroptotic signaling pathway
GO_0006915Biological processapoptotic process
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0043065Biological processpositive regulation of apoptotic process
GO_0036337Biological processFas signaling pathway
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0009897Cellular componentexternal side of plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0070062Cellular componentextracellular exosome
GO_0031265Cellular componentCD95 death-inducing signaling complex
GO_0009986Cellular componentcell surface
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0031264Cellular componentdeath-inducing signaling complex
GO_0038023Molecular functionsignaling receptor activity
GO_0019900Molecular functionkinase binding
GO_0042802Molecular functionidentical protein binding
GO_0005031Molecular functiontumor necrosis factor receptor activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFAS
Protein nameTumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor)
FAS variant
Apoptosis signaling receptor FAS
FAS 827dupA variant
Fas cell surface death receptor
FAS receptor variant 9 (Fas cell surface death receptor)
Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
FAS
SynonymsTNFRSF6
FAS1
APT1
DescriptionFUNCTION: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). .

AccessionsENST00000494799.6
ENST00000492756.7 [P25445-5]
ENST00000696771.1
A0A8V8TKN4
ENST00000697036.1 [P25445-4]
ENST00000696782.1
ENST00000697035.1
ENST00000696780.1
ENST00000696776.1
A0A8Q3WLL4
Q59FU8
P25445
A0A8Q3WLK1
A0A8Q3SJI5
S5PZ57
Q9UET8
A0A8V8TM64
ENST00000697095.1
ENST00000696779.1
A0A8Q3WM13
ENST00000479522.6 [P25445-3]
F0UWG7
ENST00000562983.3
ENST00000355279.2 [P25445-7]
A0A087WTM9
ENST00000690268.1
ENST00000696768.1
S5PSV7
ENST00000460510.6
ENST00000357339.7 [P25445-6]
E6Y7C3
ENST00000696781.1
ENST00000484444.6 [P25445-2]
ENST00000696997.1
ENST00000612663.6
ENST00000696999.1
E6Y7C4
A0A8V8TKJ0
ENST00000697097.1
ENST00000488877.6 [P25445-4]
ENST00000652046.1 [P25445-1]
K9J972
ENST00000477270.6
A0A8Q3SIR6
A0A8Q3WLI5
ENST00000355740.8
A0A8Q3WLK6
ENST00000494410.5 [P25445-4]
A0A8Q3SIY4