YAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0050673Biological processepithelial cell proliferation
GO_0097191Biological processextrinsic apoptotic signaling pathway
GO_0035265Biological processorgan growth
GO_0030216Biological processkeratinocyte differentiation
GO_1902018Biological processnegative regulation of cilium assembly
GO_0048368Biological processlateral mesoderm development
GO_0030307Biological processpositive regulation of cell growth
GO_0010629Biological processnegative regulation of gene expression
GO_0035329Biological processhippo signaling
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0060045Biological processpositive regulation of cardiac muscle cell proliferation
GO_0048339Biological processparaxial mesoderm development
GO_0060449Biological processbud elongation involved in lung branching
GO_0001829Biological processtrophectodermal cell differentiation
GO_0010628Biological processpositive regulation of gene expression
GO_0006974Biological processDNA damage response
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0001570Biological processvasculogenesis
GO_0061026Biological processcardiac muscle tissue regeneration
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0071480Biological processcellular response to gamma radiation
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0065003Biological processprotein-containing complex assembly
GO_0042060Biological processwound healing
GO_0030857Biological processnegative regulation of epithelial cell differentiation
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0072091Biological processregulation of stem cell proliferation
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0070102Biological processinterleukin-6-mediated signaling pathway
GO_0072307Biological processregulation of metanephric nephron tubule epithelial cell differentiation
GO_0060576Biological processintestinal epithelial cell development
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0002067Biological processglandular epithelial cell differentiation
GO_1904036Biological processnegative regulation of epithelial cell apoptotic process
GO_0003015Biological processheart process
GO_2000737Biological processnegative regulation of stem cell differentiation
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0003143Biological processembryonic heart tube morphogenesis
GO_1903703Biological processenterocyte differentiation
GO_0000902Biological processcell morphogenesis
GO_0050767Biological processregulation of neurogenesis
GO_0001894Biological processtissue homeostasis
GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_0010837Biological processregulation of keratinocyte proliferation
GO_0030903Biological processnotochord development
GO_0060487Biological processlung epithelial cell differentiation
GO_0032570Biological processresponse to progesterone
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0030859Biological processpolarized epithelial cell differentiation
GO_0035019Biological processsomatic stem cell population maintenance
GO_0140552Cellular componentTEAD-YAP complex
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005911Cellular componentcell-cell junction
GO_0005829Cellular componentcytosol
GO_0001674Cellular componentfemale germ cell nucleus
GO_0005737Cellular componentcytoplasm
GO_0030054Cellular componentcell junction
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0070064Molecular functionproline-rich region binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0003712Molecular functiontranscription coregulator activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameYAP1
Protein nameYes-associated protein isoform 9
Yes1 associated transcriptional regulator
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
SynonymsYAP65
DescriptionFUNCTION: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis . The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ . Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization . Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration . The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction . Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 . In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). .; FUNCTION: [Isoform 2]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). .; FUNCTION: [Isoform 3]: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). .

AccessionsENST00000282441.10 [P46937-1]
ENST00000526343.5 [P46937-5]
H0YCI3
ENST00000345877.6 [P46937-7]
ENST00000629586.2 [P46937-3]
P46937
ENST00000524575.5 [P46937-4]
K0KVU2
ENST00000529029.1
ENST00000615667.4 [P46937-9]
ENST00000537274.5 [P46937-8]
ENST00000531439.5 [P46937-2]