PIDD1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PIDD1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PIDD1 at tissue level.

III. Associated gene sets

GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0007165Biological processsignal transduction
GO_0016540Biological processprotein autoprocessing
GO_0006974Biological processDNA damage response
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0043066Biological processnegative regulation of apoptotic process
GO_0006977Biological processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO_0006915Biological processapoptotic process
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0043065Biological processpositive regulation of apoptotic process
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1905369Cellular componentendopeptidase complex
GO_0005634Cellular componentnucleus
GO_0004175Molecular functionendopeptidase activity
GO_0005123Molecular functiondeath receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePIDD1
Protein nameAlternative protein PIDD
P53-induced death domain protein 1
p53-induced death domain-containing protein 1 (EC 3.4.21.-) (Leucine-rich repeat and death domain-containing protein) [Cleaved into: PIDD-N; PIDD-C; PIDD-CC]
SynonymsLRDD
PIDD
DescriptionFUNCTION: Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis . Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis . Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B . .

AccessionsH0YE55
ENST00000531286.5
ENST00000411829.6 [Q9HB75-2]
ENST00000524486.5
ENST00000525028.6
ENST00000347755.10 [Q9HB75-1]
Q9HB75
ENST00000534649.2
L8E8G9
E9PPT6